PMID: 8950224Oct 21, 1996Paper

Structure and mechanism of formation of a new adduct from formaldehyde and guanosine

Chemico-biological Interactions
G KennedyW P Watson

Abstract

Reactions between formaldehyde and guanosine in the range pH 4-10 gave N2-hydroxymethylguanosine 1, bis-N2-guanosinylmethane 2 and 7-[7-(beta-D-ribofuranosyl)-purin-6(7H)- on-2-yl]-3-(beta-D-ribofuranosyl)-5,6,7,8-tetrahydro-sym-triazino[ 1,2-alpha] purin-10(3H)-one 3a. The latter is a new adduct, the formation of which occurs in neutral solution, is favoured at higher pH and can be rationalised by a sequence of condensations involving two molecules each of guanosine and formaldehyde.

References

Aug 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M CasanovaH D Heck
Jun 8, 1984·Journal of Chromatography·F A BelandR H Heflich
Jan 1, 1980·Annual Review of Biochemistry·S J Benkovic
Oct 1, 1954·Biochimica Et Biophysica Acta·H FRAENKEL-CONRAT

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