PMID: 2495816Jan 10, 1989Paper

Structure and negative transcriptional regulation by glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene

Biochemistry
W NorthemannG H Fey

Abstract

DNA clones representing the negative acute-phase gene coding for the plasma proteinase inhibitor alpha 1-inhibitor III were isolated from a rat genomic library. Structural analysis established the existence of at least four different members of the alpha 1-inhibitor III gene family. Partial DNA sequence analysis of the 5'-terminal regions was performed for the alpha 1-inhibitor III gene and the related alpha 1-inhibitor IV gene. The transcription start site of the alpha 1-inhibitor III gene was located by S1 mapping and primer extension. No stable alpha 1-inhibitor IV mRNA was detected in rat liver. In an experimentally induced acute-phase reaction, the transcription rate of the alpha 1-inhibitor III gene was reduced 12.7-fold at 6 h after stimulation. Four hours after injection of a high dose of dexamethasone into rats, the transcription rate of this gene was reduced 9-fold. Thus, glucocorticoids alone are capable of causing a strong transient down-regulation of the transcription of this gene in rats, independent of other inflammatory mediators. An inverted consensus glucocorticoid responsive element (5'GGACACAATAT3') shared with the glucocorticoid-regulated alpha 1-fetoprotein, alpha 2u-globulin, and alpha 1-acid glycoprotein...Continue Reading

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Citations

Nov 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K S KochH L Leffert
Aug 17, 1994·Biochimica Et Biophysica Acta·R OsterbergA Ikai
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HattoriG H Fey
Jan 12, 2007·BMC Bioinformatics·Eric YangIoannis P Androulakis
Aug 9, 2018·The Journal of Pharmacology and Experimental Therapeutics·Vivaswath S AyyarWilliam J Jusko
Nov 18, 2000·European Journal of Biochemistry·P J TatnellJ Kay
Feb 1, 1990·Molecular and Cellular Biology·R A RippeH L Leffert
Dec 20, 1988·Brain Research·W I LipkinM B Oldstone

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