PMID: 11325221Apr 28, 2001Paper

Structure and neurotrophic activity of seco-prezizaane-type sesquiterpenes from Illicium merrillianum

Journal of Natural Products
J M HuangYoshiyasu Fukuyama

Abstract

An extract of the pericarps of Illicium merrillianum has yielded four new sesquiterpenes: 3 alpha-hydroxycycloparvifloralone (1), 1,2-dehydrocycloparvifloralone (2), (11) 7,14-ortholactone-3 alpha-hydroxyfloridanolide (3), and 11-O-debenzoyltashironin (4) along with cycloparvifloralone (5), merrillianone (6), and tashironin (7). The structures of 1--4 were determined on the basis of spectroscopic analyses. 11-O-Debenzoyltashironin (4) showed neurotrophic activity in primary culture of rat cortical neurons at 0.1--10 microM. However, cycloparvifloralone-type sesquiterpenes (1, 2, 5, and 6) and tashironin (7) had no neurotrophic activity at these concentrations.

Citations

Jan 8, 2004·Chemical & Pharmaceutical Bulletin·Jian-Mei HuangYoshiyasu Fukuyama
Jun 28, 2014·Chinese Journal of Natural Medicines·Ji-Feng LiuYan-Bing Zhang
Jan 12, 2016·Journal of Asian Natural Products Research·Xin-Hui TianYun-Heng Shen
May 10, 2011·Journal of Ethnopharmacology·Guo-Wei WangLu-Ping Qin
May 13, 2015·Journal of Asian Natural Products Research·Hai-Ning LüShi-Shan Yu
Dec 15, 2016·Journal of the American Chemical Society·Kevin HungThomas J Maimone
Dec 20, 2008·Bioorganic & Medicinal Chemistry Letters·Wanxia TangYoshiyasu Fukuyama
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Feb 27, 2020·Journal of Fish Diseases·Mingzhu LiuPengfei Li
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