Structure and ovarian expression of the oxytocin gene in sheep

Reproduction, Fertility, and Development
R IvellJohn A McCracken

Abstract

In sheep, the oxytocin gene is highly up-regulated in the ovarian corpus luteum as well as in the hypothalamus. This expression is already elevated on Day 2 of the oestrous cycle, representing 1% of all transcripts in this tissue, and it declines thereafter to low levels after Day 6 of the cycle. In order to study the mechanisms involved in luteal oxytocin gene expression, we have cloned and sequenced the oxytocin gene from the sheep. This gene is closely homologous to other known mammalian oxytocin genes, especially the bovine one, and comparison of the gene promoter regions highlights several blocks of putative control elements.

Citations

Apr 29, 1993·Regulatory Peptides·R IvellH Ungefroren
Jul 20, 1999·Molecular and Cellular Endocrinology·R Ivell, N Walther
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·U WehrenbergN Walther
Oct 1, 1992·Journal of Neuroendocrinology·W S Young
Jun 12, 1992·Annals of the New York Academy of Sciences·K M Kendrick, E B Keverne
Jul 22, 1993·Annals of the New York Academy of Sciences·D C WathesV J Ayad
Sep 29, 2009·Domestic Animal Endocrinology·C S KeatorJ A McCracken
Apr 22, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Aurore CaqueretJacques L Michaud
Jun 12, 1992·Annals of the New York Academy of Sciences·J P BurbachF M de Bree
Jun 25, 2002·The Journal of Pharmacy and Pharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
Apr 30, 1999·Physiological Reviews·J A McCrackenJ C Lamsa
Oct 5, 2010·General and Comparative Endocrinology·Akihisa Urano, Hironori Ando

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