Structure and partial genomic sequence of the human E2F1 gene

Gene
E NeumanW G Kaelin

Abstract

The E2F family of transcription factors appears to play a critical role in the transcription of certain genes required for cell cycle progression. E2F1, the first cloned member of this family, is regulated during the cell cycle at the mRNA level by changes in transcription of the E2F1 gene and at the protein level by complex formation with proteins such as the retinoblastoma gene product (pRB), cyclin A and DP1. E2F1 can override a pRB-induced G1/S block and can behave as an oncogene in certain cells. E2F1 was cloned and was found to contain seven exons. The dinucleotides at the 5' and 3' splice sites of intron 4 do not agree with consensus splice site sequences. Fluorescence in situ hybridization localized E2F1 to chromosome 20q11. Knowledge of the organization of E2F1 may facilitate identification of additional E2F family members, as well as detection of E2F1 abnormalities in human tumors.

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Citations

Nov 5, 2011·Journal of Neuro-oncology·Markus J BooklandKamel Khalili
Dec 2, 2011·Molecular Pharmaceutics·Abdelkader A MetwallyIan S Blagbrough
Jan 5, 2002·Breast Cancer Research and Treatment·G H HoK J Van Zee
Jun 15, 2006·The Journal of Biological Chemistry·Jose M RodriguezW Douglas Cress
Mar 10, 2001·Molecular and Cellular Biology·R C DietrichR A Padgett
Oct 12, 2001·Biochemical and Biophysical Research Communications·Z KherroucheD Monté
Jun 17, 2014·Bioinformatics·Andrei TodorTamer Kahveci
Feb 13, 2001·Protein Expression and Purification·W ZengY Shi
Dec 21, 2012·Oncology Letters·Yunzhao ZhaoXiaoxiang Guan

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