Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling.

Immunological Reviews
Tom P MonieNicholas J Gay

Abstract

Initiation of the innate immune response requires agonist recognition by a pathogen recognition receptor. Following ligand binding, conformational rearrangement of the receptor creates a molecular scaffold from which signal transduction is propagated via complex cellular signaling pathways. This in turn leads to the induction of a pro-inflammatory immune response. A critical component of these signaling pathways is the homotypic interaction of receptor and adapter proteins via specific protein interaction domains. Within the innate immune signaling cascade, homotypic interactions between members of the death domain family and the Toll/interleukin-1 receptor domain are particularly important. Here we discuss the current understanding of the molecular basis of these homotypic receptor:adapter interactions and their role in innate immune signal transduction.

References

Jul 1, 1995·Trends in Biochemical Sciences·S McLaughlin, A Aderem
Jan 1, 1996·Annual Review of Cell and Developmental Biology·M P Belvin, K V Anderson
Aug 26, 1998·Current Biology : CB·M ThomeJ Tschopp
May 18, 1999·The Journal of Biological Chemistry·N InoharaG Núñez
Jun 26, 1999·The Journal of Biological Chemistry·H WescheZ Cao
Jul 6, 2000·The Journal of Biological Chemistry·N InoharaG Núñez
Nov 23, 2000·The Journal of Biological Chemistry·Y OguraG Nunez
Aug 16, 2001·Trends in Biochemical Sciences·C H Weber, C Vincenz
Nov 7, 2001·The Journal of Experimental Medicine·A CastrilloL Boscá
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shyun LiHolger Wesche
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Jan 16, 2003·The Journal of Biological Chemistry·Stephen E GirardinPhilippe J Sansonetti
May 31, 2003·The Journal of Biological Chemistry·Christian StehlikJohn C Reed
Jun 7, 2003·Science·Stephen E GirardinDana J Philpott
Dec 20, 2003·The EMBO Journal·Huaiyu SunSteven A Wasserman
May 5, 2004·The Journal of Biological Chemistry·Javed A KhanLiang Tong
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Jun 15, 2005·Annual Review of Biochemistry· InoharaGabriel Nuñez
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vladimir U ToshchakovStefanie N Vogel
Jul 12, 2005·FEBS Letters·Martin C MoncrieffeNicholas J Gay
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael V LaskerSatish K Nair
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Almut DufnerTak W Mak
Jan 28, 2006·The Journal of Biological Chemistry·Pearl GrayLuke A J O'Neill
Apr 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel C RoweDouglas T Golenbock

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Citations

Dec 7, 2013·Experimental & Molecular Medicine·Beom Seok Park, Jie-Oh Lee
Jun 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hidenori OhnishiMasahiro Shirakawa
May 28, 2010·The Journal of Biological Chemistry·Yue GuanRichard I Tapping
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yu Fang, Jianguo Hu
Mar 13, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiaomei WangRoland W Herzog
Oct 13, 2009·Trends in Biochemical Sciences·Tom P MonieNicholas J Gay
Apr 15, 2015·Reviews in the Neurosciences·Wang XiangDu-Yi Feng
Dec 23, 2009·Journal of Structural Biology·Jing GongShaila C Rössle
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wenji PiaoVladimir Y Toshchakov
Mar 5, 2014·Innate Immunity·Maximiliano J Jiménez-DalmaroniIan A Wilson
Jun 20, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Artur JavmenVladimir Y Toshchakov
Jan 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenji PiaoVladimir Y Toshchakov
Mar 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vladimir Y ToshchakovStefanie N Vogel
Sep 20, 2021·Journal of Molecular Biology·Dipika NandiAshish Kulkarni

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