Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation

The Journal of Immunology : Official Journal of the American Association of Immunologists
M Kathryn LiszewskiJ P Atkinson

Abstract

The outbreak of monkeypox in the Unites States in the summer of 2003 was the first occurrence of this smallpox-like disease outside of Africa. This limited human epidemic resulted from cross-infection of prairie dogs by imported African rodents. Although there were no human fatalities, this outbreak illustrates that monkeypox is an emerging natural infection and a potential biological weapon. We characterized a virulence factor expressed by monkeypox (monkeypox inhibitor of complement enzymes or MOPICE). We also compared its structure and regulatory function to homologous complement regulatory proteins of variola (SPICE) and vaccinia (VCP). In multiple expression systems, 5-30% of MOPICE, SPICE, and VCP consisted of function-enhancing disulfide-linked homodimers. Mammalian cells infected with vaccinia virus also expressed VCP dimers. MOPICE bound human C3b/C4b intermediate to that of SPICE and VCP. Cofactor activity of MOPICE was similar to VCP, but both were approximately 100-fold less efficient than SPICE. SPICE and VCP, but not MOPICE, possessed decay-accelerating activity for the C3 and C5 convertases of the classical pathway. Additionally, all three regulators possessed heparin-binding capability. These studies demonstrate...Continue Reading

References

Dec 1, 1992·The Journal of Infectious Diseases·R McKenzieM M Frank
May 1, 1985·Virology·J J Esposito, J C Knight
Oct 1, 1986·The Journal of Infectious Diseases·Z JezekM Szczeniowski
Jan 1, 1996·Advances in Immunology·M K LiszewskiJ P Atkinson
Aug 29, 2000·The Journal of Biological Chemistry·M K LiszewskiJ P Atkinson
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W G BrodbeckM E Medof
Jun 21, 2001·Immunological Reviews·M Krych-Goldberg, J P Atkinson
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ariella M RosengardRobert Jimenez
Jan 21, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
Aug 28, 2003·Microbes and Infection·Lance R DunlopAriella M Rosengard
Sep 12, 2003·Trends in Immunology·Jayati MullickArvind Sahu
Jan 15, 2004·The Lancet Infectious Diseases·Daniel B Di Giulio, Paul B Eckburg
Jan 23, 2004·The New England Journal of Medicine·Kurt D ReedInger K Damon
Jun 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vannakambadi K GaneshKrishna H M Murthy
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peter B JahrlingJohn W Huggins
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georgia SfyroeraJohn D Lambris
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malgorzata Krych-GoldbergJohn P Atkinson
Nov 23, 2005·The Journal of Biological Chemistry·Dennis E Hourcade

❮ Previous
Next ❯

Citations

Jul 31, 2007·Future Microbiology·Scott ParkerDenise A Schultz
Dec 27, 2007·Viral Immunology·Kara L CummingsYoung S Hahn
Sep 4, 2013·Journal of Biomolecular Structure & Dynamics·Ana Paula GuimarãesTanos Celmar Costa França
Jun 10, 2015·Human Genomics·M Kathryn Liszewski, John P Atkinson
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jan 29, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Galina A Shchelkunova, Sergei N Shchelkunov
Nov 1, 2016·Experimental Biology and Medicine·Hadi Abou-El-Hassan, Hassan Zaraket
Aug 31, 2018·Viruses·Scott ParkerRobert Mark Buller
Dec 12, 2007·Infection and Immunity·M Beucher, K A Norris
Jun 12, 2008·The Journal of Infectious Diseases·Pamela S HairKenji M Cunnion
Oct 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muzammil AhmadArvind Sahu
Dec 30, 2008·PLoS Pathogens·Elizabeth A MoultonR Mark L Buller
Oct 19, 2012·Journal of Virology·Malik Johid RezaArvind Sahu
Jul 18, 2014·Clinical and Vaccine Immunology : CVI·Clement A MesedaJerry P Weir
Jan 10, 2017·Frontiers in Microbiology·Elise S HovinghIlse Jongerius
Nov 30, 2018·Journal of Biomolecular Structure & Dynamics·Danielle Rodrigues GarciaTanos Celmar Costa França
Jun 9, 2020·FEBS Letters·Palak AgrawalArvind Sahu
Mar 31, 2007·The Journal of Biological Chemistry·Lisa Kuttner-KondoM Edward Medof
Aug 12, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kathryn LiszewskiJohn P Atkinson
Mar 24, 2010·The Journal of Experimental Medicine·Panisadee AvirutnanJohn P Atkinson
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kathryn LiszewskiJohn P Atkinson
Jul 4, 2017·Frontiers in Microbiology·Palak AgrawalArvind Sahu
Nov 21, 2008·Journal of Virology·Mohammed Rafii-El-Idrissi BenhniaShane Crotty
Feb 15, 2008·The Journal of General Virology·April Keim ParkerR Mark L Buller
Jan 17, 2008·Nature Reviews. Microbiology·John D LambrisBrian V Geisbrecht
Jan 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kalyani PyaramArvind Sahu
Jan 18, 2007·Immunology and Cell Biology·Marianne M StanfordGeeta Chaudhri
Dec 31, 2010·Journal of Virology·Natasha M GirgisStuart N Isaacs
Feb 13, 2021·Viruses·Anwesha SinhaArvind Sahu
Feb 7, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bailey E MaloneySherry D Fleming
Jul 1, 2014·Molecular Immunology·Hina OjhaArvind Sahu
Apr 24, 2009·Vaccine·Panisadee AvirutnanMichael S Diamond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
M Kathryn LiszewskiJ P Atkinson
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Yu LiInger K Damon
The Journal of Immunology : Official Journal of the American Association of Immunologists
Viveka Nand YadavArvind Sahu
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Gregory HuhnMatthew J Kuehnert
Microbes and Infection
Lance R DunlopAriella M Rosengard
© 2021 Meta ULC. All rights reserved