Structure and subunit arrangement of the A-type ATP synthase complex from the archaeon Methanococcus jannaschii visualized by electron microscopy.

The Journal of Biological Chemistry
Unal CoskunGerhard Gruber

Abstract

In Archaea, bacteria, and eukarya, ATP provides metabolic energy for energy-dependent processes. It is synthesized by enzymes known as A-type or F-type ATP synthase, which are the smallest rotatory engines in nature (Yoshida, M., Muneyuki, E., and Hisabori, T. (2001) Nat. Rev. Mol. Cell. Biol. 2, 669-677; Imamura, H., Nakano, M., Noji, H., Muneyuki, E., Ohkuma, S., Yoshida, M., and Yokoyama, K. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2312-2315). Here, we report the first projected structure of an intact A(1)A(0) ATP synthase from Methanococcus jannaschii as determined by electron microscopy and single particle analysis at a resolution of 1.8 nm. The enzyme with an overall length of 25.9 nm is organized in an A(1) headpiece (9.4 x 11.5 nm) and a membrane domain, A(0) (6.4 x 10.6 nm), which are linked by a central stalk with a length of approximately 8 nm. A part of the central stalk is surrounded by a horizontal-situated rodlike structure ("collar"), which interacts with a peripheral stalk extending from the A(0) domain up to the top of the A(1) portion, and a second structure connecting the collar structure with A(1). Superposition of the three-dimensional reconstruction and the solution structure of the A(1) complex from M...Continue Reading

References

May 20, 1992·Biochimica Et Biophysica Acta·N Nelson
May 26, 1999·Journal of Bioenergetics and Biomembranes·V MüllerT Lemker
Jul 3, 1999·Journal of Molecular Biology·S Karrasch, J E Walker
Sep 15, 1999·Nature·E J BoekemaJ S Lolkema
Nov 5, 1999·The Journal of Biological Chemistry·S WilkensM Forgac
Feb 12, 2000·Journal of Molecular Biology·B BöttcherP Gräber
Dec 15, 2000·Current Opinion in Structural Biology·D StockJ E Walker
Sep 5, 2001·The Journal of Biological Chemistry·S Wilkens, M Forgac
Sep 5, 2001·Nature Reviews. Molecular Cell Biology·M YoshidaT Hisabori
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·G Gruber
Jan 30, 2002·The Journal of Biological Chemistry·Ines DomgallBettina Böttcher
Feb 21, 2002·The Journal of Biological Chemistry·Unal CoskunVolker Müller
Jul 30, 2002·Journal of Molecular Biology·Janet VonckPeter Dimroth
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hiromi ImamuraKen Yokoyama
May 10, 2003·Cellular and Molecular Life Sciences : CMLS·V Müller, G Grüber
May 28, 2003·Extremophiles : Life Under Extreme Conditions·Astrid LinglVolker Müller
Jul 5, 2003·The Journal of Biological Chemistry·Tammy Bohannon Grabar, Brian D Cain
Nov 25, 2003·The EMBO Journal·John L RubinsteinRichard Henderson
Jan 27, 2004·Journal of Bioenergetics and Biomembranes·Andrew W HardyBrian D Cain
Feb 28, 2004·The Journal of Biological Chemistry·Unal CoskunGerhard Grüber

❮ Previous
Next ❯

Citations

Sep 13, 2006·Archives of Microbiology·Trees Ubbink-KokJuke S Lolkema
Mar 24, 2011·Quarterly Reviews of Biophysics·Stephen P MuenchMichael A Harrison
Feb 23, 2010·Nature Structural & Molecular Biology·Lawrence K LeeDaniela Stock
Feb 24, 2009·The Journal of Biological Chemistry·Erik Kish-Trier, Stephan Wilkens
Sep 13, 2007·Journal of the Royal Society, Interface·Julie E M McGeoch, Malcolm W McGeoch
Apr 29, 2006·Journal of Molecular Microbiology and Biotechnology·V MüllerG Grüber
Apr 3, 2008·Biology Direct·Armen Y MulkidjanianEugene V Koonin
Sep 18, 2009·Journal of Bioenergetics and Biomembranes·Shovanlal GayenGerhard Grüber
Nov 27, 2007·Journal of Molecular Biology·Erik Kish-TrierStephan Wilkens
Oct 22, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gerhard Grüber, Vladimir Marshansky
Jan 5, 2005·Micron : the International Research and Review Journal for Microscopy·Stephan WilkensYesha Zheng
May 14, 2005·Journal of Molecular Biology·David VenzkeBettina Böttcher
Feb 11, 2014·Biochimica Et Biophysica Acta·Vladimir MarshanskyGerhard Grüber
Mar 22, 2014·Biochimica Et Biophysica Acta·Gerhard GrüberVolker Müller
Jan 14, 2009·Journal of Structural Biology·Malathy Sony Subramanian ManimekalaiGerhard Grüber
Dec 27, 2006·Journal of Molecular Biology·Neratur K LokanathNaoki Kunishima
Jun 15, 2011·Biochimica Et Biophysica Acta·Cornelia HunkeGerhard Grüber
Jun 30, 2006·Biochimica Et Biophysica Acta·Kim Lewalter, Volker Müller
May 16, 2006·Biochimica Et Biophysica Acta·John E Walker, Veronica Kane Dickson
Oct 19, 2005·Advances in Protein Chemistry·Stephan Wilkens
Dec 27, 2005·Journal of Structural Biology·Christoph GerleKaoru Mitsuoka
Aug 18, 2016·Science Advances·Mohammad T Mazhab-Jafari, John L Rubinstein
Mar 15, 2006·American Journal of Medical Genetics. Part a·Eva MoravaJan Smeitink
Dec 7, 2007·The Journal of Biological Chemistry·Olga EstebanDaniela Stock
Sep 21, 2018·Frontiers in Physiology·Lilia Colina-TenorioDiego González-Halphen
Nov 9, 2011·Biophysics·Christoph Gerle
Jul 2, 2019·Molecular Membrane Biology·Bjørn P PedersenHans-Jürgen Apell

❮ Previous
Next ❯

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.