Structure, assembly and homeostatic regulation of the 26S proteasome

Journal of Molecular Cell Biology
Youming Xie

Abstract

The 26S proteasome is the major protease responsible for degradation of regulatory and abnormal proteins in the cell. Proteasomal degradation controls many cellular processes including, but not limited to, cell cycle control, transcription, DNA repair, apoptosis, quality control and antigen presentation. To elucidate how the proteasome is regulated is crucial to our understanding of the molecular details of proteasomal degradation and its functions in diverse biological pathways. In this article, I will highlight recent advances in understanding the proteasome structure and assembly and the regulation of proteasome gene expression. The implications of these new developments in cancer therapy will also be discussed.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KumatoriA Ichihara
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·Maria GaczynskaAlfred L Goldberg
Nov 1, 1993·Journal of Structural Biology·T YoshimuraWolfgang Baumeister
Jan 1, 1996·Current Topics in Cellular Regulation·L Hoffman, Martin Rechsteiner
Jan 1, 1996·Annual Review of Biochemistry·O CouxAlfred L Goldberg
Apr 3, 1997·Nature·Michael GrollRobert Huber
Jun 20, 1998·Molecular and Cellular Biology·M H GlickmanDaniel Finley
Mar 12, 1999·Annual Review of Medicine·A L Schwartz, Aaron Ciechanover
Jun 8, 1999·Annual Review of Immunology·K L Rock, Alfred L Goldberg
Jul 27, 1999·The Journal of Biological Chemistry·S J RussellS A Johnston
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·Youming Xie, Alexander Varshavsky
Jun 29, 2000·Annual Review of Biochemistry·D VogesWolfgang Baumeister
Jul 13, 2000·Molecular Cell Biology Research Communications : MCBRC·T A GriffinR A Colbert
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·L BurriF Lévy
Oct 4, 2000·Nature Medicine·A HershkoAlexander Varshavsky
Nov 18, 2000·Nature·Frank G WhitbyChristopher P Hill
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Youming Xie, Alexander Varshavsky
Mar 30, 2001·The Journal of Biological Chemistry·J You, Cecile M Pickart
Dec 12, 2001·The Journal of Biological Chemistry·Cezary Wójcik, George N DeMartino
May 17, 2002·Structure·Masaki UnnoTomitake Tsukihara
Jun 8, 2002·Molecular and Cellular Biology·Li Chen, Kiran Madura
Nov 1, 2002·Molecular Cell·David S LeggettDaniel Finley
Nov 26, 2002·Nature Cell Biology·Youming Xie, Alexander Varshavsky
Dec 31, 2002·Archives of Biochemistry and Biophysics·Yayoi KimuraHisashi Hirano
Feb 18, 2003·Molecular and Cellular Biology·Alessandro FaticaDavid Tollervey
Nov 13, 2003·Molecular and Cellular Biology·Mi-Kyoung KwakThomas W Kensler
Dec 17, 2003·Cell·Fengxue ZhangJeffrey E Kudlow
Jan 24, 2004·The EMBO Journal·Irina VelichutinaMark Hochstrasser
Mar 3, 2004·Nature Reviews. Molecular Cell Biology·Cecile M Pickart, Robert E Cohen
Apr 22, 2004·Journal of Structural Biology·Andrey V KajavaAlasdair C Steven
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christos N PapandreouChristopher J Logothetis
Jun 5, 2004·FEBS Letters·Markus K LondonR Jürgen Dohmen
Sep 11, 2004·Biochemical and Biophysical Research Communications·Donghong JuYouming Xie
Nov 10, 2004·Journal of Molecular Biology·Miranda StoneColin Gordon
Nov 10, 2004·PLoS Biology·Audrey P GaschMichael B Eisen
Jan 29, 2005·Chembiochem : a European Journal of Chemical Biology·Michael GrollRobert Huber
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Christian PilarskyRobert Grützmann
Jan 25, 2006·Biochemical and Biophysical Research Communications·Donghong Ju, Youming Xie
May 26, 2006·Biochemical and Biophysical Research Communications·Mi-Kyoung Kwak, Thomas W Kensler
Jul 22, 2006·Circulation Research·Chenggong ZongPeipei Ping
Aug 22, 2006·Journal of Structural Biology·David M SmithAlfred L Goldberg
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Dec 1, 2006·Molecular Biology of the Cell·Erika IsonoAkio Toh-e
Mar 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amalia MilanoFrancesco Caponigro
Jun 2, 2007·Science·Shigeo MurataKeiji Tanaka
Oct 3, 2007·Journal of Molecular Evolution·Gertrud Mannhaupt, Horst Feldmann
Nov 21, 2007·Nature Structural & Molecular Biology·Maurits F KleijnenDaniel Finley
Feb 19, 2008·Nature Structural & Molecular Biology·Andrew R KusmierczykMark Hochstrasser
Feb 19, 2008·Nature Structural & Molecular Biology·Hideki YashirodaKeiji Tanaka
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert Z Orlowski, Deborah J Kuhn
May 13, 2008·Molecular Cell·Julius RablYifan Cheng
May 31, 2008·Nature Structural & Molecular Biology·Rina RosenzweigMichael H Glickman
Jun 7, 2008·The Journal of Biological Chemistry·Paula C A da Fonseca, Edward P Morris
Jul 25, 2008·The EMBO Journal·Yuko HiranoShigeo Murata
Dec 10, 2008·Biochemical and Biophysical Research Communications·Youichi SatoYutaka Nakahori
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·Shigeo MurataKeiji Tanaka
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Mar 7, 2009·Chemical Reviews·António J MarquesR Jürgen Dohmen
Apr 14, 2009·Journal of Molecular Biology·Grégory EffantinAlasdair C Steven
Apr 14, 2009·The Journal of Biological Chemistry·Noa MedaliaAmi Navon
May 5, 2009·Nature·Jeroen RoelofsDaniel Finley
Jun 6, 2009·Annual Review of Biochemistry·Daniel Finley
Jul 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephan NickellWolfgang Baumeister
Oct 21, 2009·Nature Chemical Biology·Erin K SchraderAndreas Matouschek
Jan 14, 2010·The Journal of Biological Chemistry·Suzanne KapetaEfstathios S Gonos
Mar 17, 2010·Molecular Cell·Kianoush Sadre-BazzazChristopher P Hill
May 18, 2010·Biochemical and Biophysical Research Communications·Keisuke FukunagaYasushi Saeki
Jun 3, 2010·Molecular and Cellular Biology·Roman HolicVeronica P C C Yu
Jul 14, 2010·Molecular Cell·Andrea LehmannCordula Enenkel
Mar 1, 1992·Applied Optics·H Lochbihler, P Predehl

Citations

Aug 25, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Meng ZhaoGuo-Qiang Chen
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Felix HaulerLeo C James
May 6, 2011·Molecular & Cellular Proteomics : MCP·Charity T AikenLan Huang
Aug 15, 2012·Molekuliarnaia biologiia·Ludmila V SpirinaO N Asadchikova
Mar 8, 2012·Chest·István VadászJacob I Sznajder
Jun 6, 2012·Annual Review of Biochemistry·Alexander Varshavsky
Jun 13, 2014·Cellular and Molecular Life Sciences : CMLS·Jerry Vriend, Russel J Reiter
Sep 16, 2014·Life Sciences·Jerry Vriend, Russel J Reiter
Sep 11, 2012·Toxicology and Applied Pharmacology·Sanghwan LeeMi-Kyoung Kwak
Mar 31, 2016·Journal of Cellular and Molecular Medicine·Kundlik GadhaveMaria Balea
Sep 2, 2015·Immunotherapy·Samuel Troy PellomAnil Shanker
Jun 30, 2015·Cytokine & Growth Factor Reviews·Spiros A VlahopoulosGeorge P Chrousos
Mar 20, 2013·Biochimica Et Biophysica Acta·Mary J Kunjappu, Mark Hochstrasser
Apr 8, 2014·The Journal of Medical Investigation : JMI·Taigo HoriguchiTakafumi Noma
Mar 15, 2015·Neurobiology of Disease·Pedro Barroso-ChineaMarie-Laure Martin-Negrier
Apr 1, 2014·Free Radical Biology & Medicine·Niki ChondrogianniEfstathios S Gonos
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Makoah Nigel AminakeGabriele Pradel
Oct 26, 2013·Progress in Neurobiology·Margarida V CaldeiraCarlos B Duarte
May 29, 2012·Chemistry & Biology·Marcus J C LongLizbeth Hedstrom
Oct 27, 2015·Immunological Reviews·Stian FossJan Terje Andersen
Nov 28, 2013·Annual Review of Genetics·Maximilian Wei-Lin Popp, Lynne E Maquat
May 27, 2014·The Journal of Organic Chemistry·Elena N GulakovaOlga A Fedorova
Sep 27, 2016·International Journal of Molecular Sciences·Rosanna PalumboGianna Palmieri
Oct 19, 2017·Cancer Metastasis Reviews·Yulin ChenXing Guo
Mar 23, 2012·Chembiochem : a European Journal of Chemical Biology·Luigi MargarucciAgostino Casapullo
Jun 27, 2018·Molecular and Cellular Biology·Hiroki SekineHozumi Motohashi
Jul 17, 2012·Bioorganicheskaia khimiia·I V KondakovaE M Slonimskaia
Feb 13, 2013·The Journal of Urology·Phillip P Smith, George A Kuchel
Jun 20, 2012·Molecular Biology Reports·Ludmila V SpirinaOlga V Shpileva
Jun 3, 2011·Protein Science : a Publication of the Protein Society·Alexander Varshavsky
Apr 22, 2017·Frontiers in Neuroscience·Aaron Ciechanover, Yong Tae Kwon
May 26, 2017·Open Biology·Shuangwu SunXin-Hua Feng
Aug 20, 2018·Bulletin of Experimental Biology and Medicine·E S KolegovaN P Sharova
Sep 29, 2017·S. G. Afanas’evL. A. Kolomiets

Related Concepts

26S proteasome
Feedback, Biochemical
Ubiquitin-protein ligase
Ingensin
Antigens
Cell Cycle
Gene Expression
Peptide Hydrolases
Transcription, Genetic
Apoptosis

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