PMID: 9552155Apr 29, 1998Paper

Structure-based design of model proteins

Proteins
J R BanavarS Vishveshwara

Abstract

A structure-based, sequence-design procedure is proposed in which one considers a set of decoy structures that compete significantly with the target structure in being low energy conformations. The decoy structures are chosen to have strong overlaps in contacts with the putative native state. The procedure allows the design of sequences with large and small stability gaps in a random-bond heteropolymer model in both two and three dimensions by an appropriate assignment of the contact energies to both the native and nonnative contacts. The design procedure is also successfully applied to the two-dimensional HP model.

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Citations

Jul 1, 2006·BMC Bioinformatics·Claudia L KleinmanNicolas Lartillot

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