Structure, biosynthesis and possible function of tunichromes and related compounds

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Manickam Sugumaran, William E Robinson

Abstract

Several species of ascidians (phylum Chordata, subphylum Urochordata) contain a group of oligopeptides called "tunichromes" in their blood cells. These peptides have been implicated in (a) metal chelation and accumulation/sequestration of vanadium or iron; (b) crosslinking of structural fibers in tunic formation, (c) wound healing and (d) defense reactions. However, their biosynthesis, metabolism, and biological function remain largely un-elucidated due to their extreme instability and high reactivity. Tunichromes and related compounds uniquely possess dehydrodopamine moieties, all originating from post-translational modification of peptidyl tyrosine. It is conceivable that the presence of such novel post-translationally modified groups provide attributes that are crucial for their biological roles. Therefore, we examined the chemistry and reactivity of tunichromes in light of the available knowledge of the biochemistry of simple monomeric dehydro-N-acyldopamine units. Based on the reactivity of such simple compounds, the potential biological activities of tunichromes are predicted. Their possible biosynthetic route from peptidyl tyrosine is critically evaluated to provide a better basis for unraveling their biological function...Continue Reading

References

Sep 15, 1979·Experientia·L BotteM de Vincentiis
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R M Carlson
May 15, 1991·Biochemical and Biophysical Research Communications·M Sugumaran, K Nellaiappan
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J H Waite
Jan 1, 1990·Archives of Insect Biochemistry and Physiology·M Sugumaran, K Nellaiappan
Jan 1, 1990·Archives of Insect Biochemistry and Physiology·M SugumaranH Dali
Mar 1, 1986·Journal of Natural Products·R C BrueningK Kustin
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·W E RobinsonK Kustin
Jun 1, 1981·Archives of Biochemistry and Biophysics·C C Winterbourn
Feb 11, 1982·Nature·V L ScofieldI L Weissman
Jul 22, 1982·Biochimica Et Biophysica Acta·A L DingleyM F Roberts
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M HallJ H Law
Nov 1, 1994·Journal of Inorganic Biochemistry·S W TaylorG R Hanson
Jan 1, 1995·Archives of Insect Biochemistry and Physiology·M Sugumaran, D Ricketts
Feb 1, 1993·Chemico-biological Interactions·D C ThompsonP Moldéus
Mar 1, 1993·Developmental and Comparative Immunology·A D JacksonC M Peddie
Jun 14, 1996·Biochemical Pharmacology·T KawabataL Packer
Aug 15, 1996·Journal of Inorganic Biochemistry·K KustinK Spartalian
Sep 1, 1996·Biochemistry and Molecular Biology International·A C RinaldiE Sanjust
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S SatoH Yamamoto
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S HataH Yokosawa
Jan 7, 1999·Developmental and Comparative Immunology·L BallarinA Sabbadin
Feb 7, 2001·Biochemical and Biophysical Research Communications·J A TincuS W Taylor
Jul 19, 2000·Insect Biochemistry and Molecular Biology·M R ChaseM Sugumaran
Aug 30, 2000·Toxicology·J P Kehrer
Sep 9, 2000·The Journal of Biological Chemistry·S W TaylorR I Lehrer
Feb 7, 2001·Molecular Biology and Evolution·T Burmester

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Citations

Jun 15, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Gillian MorrisChad D Tatko
Sep 23, 2016·International Journal of Molecular Sciences·Manickam Sugumaran
Nov 19, 2015·Metallomics : Integrated Biometal Science·Mark R Zierden, Ann M Valentine
Jan 21, 2015·Marine Drugs·Hee Kyoung KangYoonkyung Park
Jun 1, 2018·Metallomics : Integrated Biometal Science·E David ThompsonChris N Glover
Mar 5, 2019·Chembiochem : a European Journal of Chemical Biology·Nediljko Budisa, Tobias Schneider
Jan 7, 2014·Natural Product Reports·John W BluntMichèle R Prinsep
Jul 12, 2017·Organic & Biomolecular Chemistry·Hugo K H FongBrent R Copp
Jul 25, 2019·Materials·Shweta SharmaArthur D Tinoco
Jul 14, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Corey J Herbst-GervasoniAnn M Valentine
Jun 27, 2017·Frontiers in Immunology·Nicola Franchi, Loriano Ballarin
Feb 13, 2021·International Journal of Molecular Sciences·Ryo KishidaHideaki Kasai

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