PMID: 9428681Jan 15, 1998Paper

Structure, catalysis and supramolecular assembly of adenylate kinase from maize

European Journal of Biochemistry
K WildG E Schulz

Abstract

The crystal structure of adenylate kinase from maize ligated with an inhibitor has been determined by molecular replacement and refined to 3.5-A resolution. The enzyme keeps the ATP/ADP/AMP equilibrium in the cell. In the C4 plant maize, it has the special task to recycle the AMP produced in large amounts in primary CO2 assimilation. The established structure explains the side reaction with CMP. Moreover, it shows infinite rods that can be readily discerned in the crystal packing. In comparison with homologues, two structural differences that are crucial for this supramolecular assembly are evident. We propose that the rods represent a natural inactive storage form that assembles at night when maize stops CO2 assimilation and thus most of the AMP production in its C4 cycle. The enzyme is particularly abundant in mesophyll chloroplasts, where such an assembly would release appreciable amounts of water that can be used in other processes during the night.

References

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Citations

Jul 16, 2003·Journal of Molecular Biology·Angela R CriswellGeorge N Phillips
May 27, 2009·International Journal of Molecular Sciences·Petras Dzeja, Andre Terzic
Oct 27, 2009·Journal of Molecular Biology·Georg E Schulz
Sep 16, 2009·Journal of Molecular Biology·Oliver BecksteinThomas B Woolf
Jan 10, 2009·The International Journal of Biochemistry & Cell Biology·Rujuan LiuHaining Zhu
Dec 17, 2008·Biochemical and Biophysical Research Communications·Rujuan LiuWeimin Gong
Sep 6, 2005·Journal of Molecular Biology·Paul Maragakis, Martin Karplus
Sep 6, 2005·Journal of Molecular Biology·Guillaume HibleJacqueline Cherfils
May 24, 2011·Enzyme Research·Claudio A PereiraMariana R Miranda
Oct 12, 2010·Bio Systems·Abir U Igamberdiev, Leszek A Kleczkowski
Aug 23, 2018·Angewandte Chemie·Hector Garcia-SeisdedosEmmanuel D Levy
Sep 8, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·A MukhopadhyayJ Trincão
Dec 28, 2019·Marine Drugs·Dragutin PerinaHelena Ćetković
May 21, 2003·The Journal of Experimental Biology·Petras P Dzeja, Andre Terzic
Mar 16, 2016·ACS Synthetic Biology·Alicia M JonesJonathan J Silberg

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