Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes

Gene
U Janssen-TimmenP Charnay

Abstract

The structure of Krox-24, a mouse zinc-finger-encoding gene that is transiently activated during G0/G1 transition, has been established. Krox-24 is located on mouse chromosome 18, bands C-D. The gene product, as anticipated for a putative DNA-binding protein, is localized within the cell nucleus. The Krox-24 5'-flanking region contains a series of serum response elements (SREs) similar to the SRE observed upstream of the c-fos proto-oncogene. These elements can substitute for the c-fos SRE, their effect is cumulative and they bind the same cellular factor, the serum response factor (SRF), as the c-fos SRE. This suggests that the SRE and its cognate protein are likely to be involved in the regulation of Krox-24 and presumably of other immediate-early serum response genes. SRE and SRF therefore constitute key components in the regulatory pathway leading from mitogenic stimulation to cellular proliferation.

References

Jul 28, 1988·Nature·P Sassone-CorsiI M Verma
Jan 15, 1988·Cell·R M Evans, S M Hollenberg
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies

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Citations

Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A Ashworth, P Denny
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M T Davisson, K R Johnson
Nov 1, 1991·Mechanisms of Development·T el-Baradi, T Pieler
Sep 17, 1999·The American Journal of Pathology·K A KelleyG M Pasinetti
Jul 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·D M Cohen
Sep 2, 1998·Molecular and Cellular Endocrinology·J C Rodríguez-ManzanequeA Santos
Aug 15, 2013·Nature Reviews. Neuroscience·Hilmar Bading
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D CalifanoV de Franciscis
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y Collaço-MoraesJ de Belleroche
May 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A TrabandtS Gay
Feb 18, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Beatriz Pérez-CadahíaJames R Davie
Feb 16, 2006·Archives of Histology and Cytology·Shampa De, Jack E Turman
Nov 24, 2004·Progress in Neurobiology·Ewelina Knapska, Leszek Kaczmarek
May 8, 2001·Experimental Cell Research·W Zhang, S Chen
Oct 9, 2002·Neuron·Liliana MinichielloMartin Korte
Nov 11, 2008·Biochimica Et Biophysica Acta·Raymond LiuSusan M Parkhurst
Jan 1, 1992·DNA Sequence : the Journal of DNA Sequencing and Mapping·A Chestier, P Charnay
Jul 1, 1990·Molecular and Cellular Biology·P LemaireP Charnay
Nov 1, 1991·Molecular and Cellular Biology·C E Dowzer, J M Kelly

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