PMID: 406Nov 1, 1975

Structure, composition, physical properties, and turnover of proliferated peroxisomes. A study of the trophic effects of Su-13437 on rat liver

The Journal of Cell Biology
Federico LeightonCecilia Koenig


Peroxisome proliferation has been induced with 2-methyl-2-(p-[1,2,3,4-tetrahydro-1-naphthyl]-phenoxy)-propionic acid (Su-13437). DNA, protein, cytochrome oxidase, glucose-6-phosphatase, and acid phosphatase concentrations remain almost constant. Peroxisomal enzyme activities change to approximately 165%, 50%, 30%, and 0% of the controls for catalase, urate oxidase, L-alpha-hydroxy acid oxidase, and D-amino acid oxidase, respectively. For catalase the change results from a decrease in particle-bound activity and a fivefold increase in soluble activity. The average diameter of peroxisome sections is 0.58 +/- 0.15 mum in controls and 0.73 +/- 0.25 mum after treatment. Therefore, the measured peroxisomal enzymes are highly diluted in proliferated particles. After tissue fractionation, approximately one-half of the normal peroxisomes and all proliferated peroxisomes show matric extraction with ghost formation, but no change in size. In homogenates submitted to mechanical stress, proliferated peroxisomes do not reveal increased fragility; unexpectedly, Su-13437 stabilizes lysosomes. Our results suggest that matrix extraction and increased soluble enzyme activities result from transmembrane passage of peroxisomal proteins. The changes...Continue Reading


Oct 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A B Novikoff, S Goldfischer
Jan 1, 1971·The Journal of Cell Biology·M Locke, J T McMahon
Dec 29, 1972·The Journal of Membrane Biology·R D MacGregor, C A Tobias
Oct 15, 1973·FEBS Letters·M Bronfman, H Beaufay
May 1, 1969·The Journal of Cell Biology·Federico LeightonC De Duve
Jan 1, 1970·Annual Review of Biochemistry·R T Schimke, D Doyle
Aug 1, 1973·The Journal of Cell Biology·A H Huang, H Beevers
Oct 1, 1967·The Journal of Cell Biology·D SvobodaD L Azarnoff
Sep 1, 1972·Toxicology and Applied Pharmacology·R B BeckettR J Cenedella
Sep 26, 1972·Biochemical and Biophysical Research Communications·J TwetoA R Larrabee
May 1, 1971·Archives of Biochemistry and Biophysics·J L Haining
Dec 19, 1969·Annals of the New York Academy of Sciences·R W Breidenbach
Dec 19, 1969·Annals of the New York Academy of Sciences·C De Duve
Nov 4, 1969·Biochimica Et Biophysica Acta·R S Holmes, C J Masters
Sep 1, 1969·Journal of Atherosclerosis Research·G Hartmann, G Forster
Jul 27, 1970·Biochimica Et Biophysica Acta·R N Feinstein, C Peraino
Aug 1, 1966·The Journal of Cell Biology·D Svoboda, D L Azarnoff
Aug 1, 1959·The Journal of Biophysical and Biochemical Cytology·H S BENNETT, J H LUFT
May 1, 1965·The Journal of Cell Biology·J H VENABLE, R COGGESHALL
Nov 1, 1971·Plant Physiology·A H Huang, H Beevers


Nov 18, 2000·Journal of Biochemical and Molecular Toxicology·F A Nicholls-GrzemskiP C Burcham
Jul 1, 1986·Archives of Toxicology·D Thines-SempouxJ Roba
Jan 1, 1985·Anatomy and Embryology·K Gorgas
Oct 1, 1986·Pflügers Archiv : European journal of physiology·J SeydouxL Girardier
Nov 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·L F Panchenko, V D Antonenkov
Jan 1, 1986·The Journal of Membrane Biology·P LabarcaFederico Leighton
Mar 29, 2006·Cellular and Molecular Life Sciences : CMLS·K Pahan
Oct 12, 2007·Histochemistry and Cell Biology·S YokotaToshiaki Oda
Feb 16, 2008·Histochemistry and Cell Biology·Michael Schrader, H D Fahimi
Feb 21, 2009·Histochemistry and Cell Biology·S Yokota, H Dariush Fahimi
May 1, 1977·European Journal of Pharmacology·C RozéC Debray
Jan 1, 1985·The International Journal of Biochemistry·V D Antonenkov, L F Panchenko
Jan 1, 1991·The International Journal of Biochemistry·F A ReubsaetL A Monnens
May 1, 1994·The International Journal of Biochemistry·J ChandogaG Hocman
Feb 1, 1989·Molecular and Cellular Endocrinology·J P GiacobinoL Girardier
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F BieriP Bentley
Apr 1, 1989·Journal of Ultrastructure and Molecular Structure Research·J Meijer, B A Afzelius
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P B Lazarow, C De Duve
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Manuel J SantosFederico Leighton
Feb 1, 1980·European Journal of Biochemistry·S MiyazawaT Hashimoto
Sep 1, 1992·Cell Biochemistry and Function·W W Just, U Soto
Apr 25, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco Fidaleo, C Sartori
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonella PellicoroKlaas Nico Faber
May 15, 1991·Biochemical and Biophysical Research Communications·H SakurabaT Noguchi
Oct 13, 2011·IUBMB Life·Junji EzakiTakashi Ueno
Jun 13, 1979·Biochemical and Biophysical Research Communications·M BronfmanFederico Leighton
Sep 1, 1979·Archives of Biochemistry and Biophysics·T Noguchi, Y Takada
Nov 15, 1987·Analytical Biochemistry·A W WolkoffT Goeser
Jun 15, 1989·Biochemical and Biophysical Research Communications·H SakurabaT Noguchi
Jun 1, 1981·Experimental and Molecular Pathology·J T YarringtonJ P Gibson
Apr 1, 1980·Experimental and Molecular Pathology·I EggensG Dallner
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H Gray, Felix A de la Iglesia
Jan 1, 1982·Annals of the New York Academy of Sciences·Federico LeightonM Bronfman
Jan 1, 1982·Annals of the New York Academy of Sciences·G P Mannaerts, L J Debeer
Jan 1, 1982·Annals of the New York Academy of Sciences·J K ReddyN D Lalwani
Apr 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W W JustH Schimassek
Oct 15, 1986·Biochemical and Biophysical Research Communications·Cetna SkorinFederico Leighton
May 15, 1977·Biochemical Pharmacology·W G LevineL A Stocken
Nov 30, 1989·Biochemical and Biophysical Research Communications·S HayashiT Noguchi
Apr 30, 1984·Biochemical and Biophysical Research Communications·Federico LeightonC Necochea
Jul 1, 1979·Hoppe-Seyler's Zeitschrift für physiologische Chemie·T NoguchiY Oota
Jan 23, 1991·Biochimica Et Biophysica Acta·P P Van VeldhovenG P Mannaerts
Feb 1, 1982·Toxicologic Pathology·Felix A de la Iglesia, Emmanuel Farber
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S YokotaH D Fahimi
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Cecilia KoenigManuel J Santos
Oct 6, 2005·The Journal of Biological Chemistry·Manuel J SantosNibaldo C Inestrosa
May 25, 2007·The Journal of Biological Chemistry·Markus IslingerAlfred Völkl
Oct 1, 1987·Journal of the American Geriatrics Society·C N OliverE R Stadtman
Apr 14, 2016·Biochemical Society Transactions·Katarzyna Zientara-Rytter, Suresh Subramani
Nov 30, 2018·Journal of Applied Toxicology : JAT·Eun-Jung ParkKyuhong Lee

Related Concepts

Acid Phosphatase
Catalase T
Cell Fractionation
D-Amino Acid Dehydrogenase
Hydroxy Acids

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.