Structure, cytotoxicity, and DNA-cleavage properties of the complex [Cu(II)(pbt)Br2

Inorganic Chemistry
Palanisamy Uma MaheswariJan Reedijk

Abstract

The reactions of the ligand 2-(2-pyridyl)benzthiazole (pbt) with CuBr 2 and ZnCl 2 in acetonitrile produce the complexes [Cu(pbt)Br 2] ( 1) and [Zn(pbt)Cl 2] ( 3), respectively. When complex 1 is dissolved in DMF, complex 2 is obtained as light-green crystals. The reaction of pbt with CuBr 2 in DMF also yields the complex [Cu(pbt)Br 2(dmf)] ( 2) (dmf = dimethylformamide). Complexes 1- 3 were characterized by X-ray crystallography. Complexes 1 and 3 have distorted tetrahedral coordination environments, and complex 2 is constituted of two slightly different copper centers, both exhibiting distorted trigonal bipyramidal geometries. Complexes 1 and 2 cleave phiX174 phage DNA, both in the presence and the absence of reductant. The free ligand pbt does not show any DNA-cleaving abilities. The poor solubility of complex 3 makes it not applicable for biological tests. The occurrence of DNA breaks in the presence of various radical scavengers suggests that no diffusible radicals are involved in the DNA cleavage by complex 1, as none of the scavengers inhibit the cleavage reaction. The DNA-cleavage products are not religated with the enzyme T4 DNA ligase, which is an additional proof that the cleavage is nonhydrolytic. Most probably the ...Continue Reading

References

Apr 25, 1986·Science·P B Dervan
Apr 26, 1969·Nature·B RosenbergV H Mansour
Oct 24, 1998·Bioorganic & Medicinal Chemistry·S L Schreiber
May 15, 2001·Biochemical and Biophysical Research Communications·E M YazlovitskayaD L Persons
Aug 7, 2001·Inorganic Chemistry·R D WillettC Nagy
Dec 4, 2001·Journal of Inorganic Biochemistry·M S MelvinR A Manderville
Dec 26, 2001·Chemical Reviews·C Orvig, M J Abrams
Dec 26, 2001·Chemical Reviews·E Wong, C M Giandomenico
Dec 26, 2001·Chemical Reviews·E R Jamieson, S J Lippard
Dec 26, 2001·Chemical Reviews·C A Claussen, E C Long
Feb 19, 2002·Chemical Reviews·J. A. Cowan
Feb 19, 2002·Chemical Reviews·Wendy Knapp Pogozelski, Thomas D. Tullius
Feb 19, 2002·Chemical Reviews·Cynthia J. Burrows, James G. Muller
Feb 19, 2002·Chemical Reviews·Richard M. Burger
Jul 11, 2002·Chemical Reviews·Scott E Wolkenberg, Dale L Boger
Jul 15, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Srecko I KirinNils Metzler-Nolte
Oct 30, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul de HoogJan Reedijk
May 19, 2005·Chemical Communications : Chem Comm·Fabrizio MancinUmberto Tonellato
Jun 9, 2005·Journal of the American Chemical Society·Yan Jin, J A Cowan
Jan 19, 2006·Journal of the American Chemical Society·Palanisamy Uma MaheswariJan Reedijk
Mar 28, 2007·Chemistry : a European Journal·Palanisamy Uma MaheswariJan Reedijk
Aug 19, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Palanisamy Uma MaheswariJan Reedijk
Nov 5, 2001·Angewandte Chemie·Jun PangSuning Wang

❮ Previous
Next ❯

Citations

Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicola J FarrerPeter J Sadler
Mar 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Rangasamy LoganathanMohamad Abdulkadhar Akbarsha
Apr 12, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Dharmasivam MahendiranAziz Kalilur Rahiman
Jun 16, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Paramasivam JaividhyaMallayan Palaniandavar
Mar 22, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Arnab BhattacharyyaAkhil R Chakravarty
May 9, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Rangasamy LoganathanMohamad Abdulkadhar Akbarsha
Aug 16, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Graciela Aparecida Dos Santos SilvaRosely A Peralta
Feb 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Jin-Tao WangLiang-Nian Ji
Aug 16, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Roman BuchtíkZdeněk Dvořák
Jan 18, 2019·Anti-cancer Agents in Medicinal Chemistry·Yasin TülüceHalil Özkol
Dec 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Jing QianShiping Yan
Nov 22, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Lucía Álvarez-MiguelDaniel Miguel
Jan 17, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ming-Xiong TanHong Liang
Sep 6, 2017·Acta Crystallographica. Section C, Structural Chemistry·Satish S BhatN K Lokanath
Dec 18, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrew KellettMichael Devereux
Oct 7, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Basudev MaityAkhil R Chakravarty
Mar 27, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Mani AlagesanNallasamy Dharmaraj
Jun 28, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Tridib K GoswamiAkhil R Chakravarty
Aug 7, 2014·Metallomics : Integrated Biometal Science·Rosa F BrissosPatrick Gamez
Jul 9, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Louise E KaragiannidisMark I Ogden
Jul 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Lüying LiLiangnian Ji
Jul 9, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Sudipta BhattacharyyaTapas K Sengupta
Dec 3, 2011·Metallomics : Integrated Biometal Science·Wan Yen LeeKok Hwa Lim
Feb 18, 2021·Inorganic Chemistry·Quim PeñaÒscar Palacios
Aug 3, 2010·Chemical Research in Toxicology·Yi ShiJames C Dabrowiak
Jan 9, 2020·ACS Combinatorial Science·Nazanin KordestaniOlivier Blacque
Aug 12, 2009·Journal of Inorganic Biochemistry·Oluwatayo F IkotunRobert P Doyle
Jun 16, 2009·Journal of Inorganic Biochemistry·Nicolás A ReyElene C Pereira-Maia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.