Structure determination of a sildenafil analogue contained in commercial herb drinks

Magnetic Resonance in Chemistry : MRC
Choonshik ShinYoongho Lim

Abstract

It was found from HPLC analysis that a commercial herb drink contains a putative sildenafil analog. In order to identify the sildenafil-like compound, separation and purification were carried out. The structure determination was performed based on routine 1D and 2D NMR experiments. Unlike sildenafil, the compound contains an ethylpiperazine instead of a methylpiperazine group. In addition, the piperazine and phenyl groups are connected through an acetyl group instead of the sulfonyl group of sildenafil.

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Citations

Oct 11, 2011·Journal of Agricultural and Food Chemistry·Choonshik ShinShin Jung Kang
Mar 17, 2007·Food Additives and Contaminants·H J ParkS W Kwon
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Jan 24, 2006·Journal of Pharmaceutical and Biomedical Analysis·Maciej J BoguszMohammed Al-Tufail

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