Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii

Journal of Asian Natural Products Research
Dan ZhaoYue-Hu Pei

Abstract

Two new 13,14:14,15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6 μM, respectively, compared to the positive control 5-fluorouracil (6.4 μM).

References

Nov 13, 2007·Journal of Asian Natural Products Research·Li-Qin WangQi-Tai Zheng
Jul 15, 2011·Journal of Asian Natural Products Research·Gang ChenYue-Hu Pei
Sep 21, 2013·Carbohydrate Research·Chung Sub KimKang Ro Lee

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Methods Mentioned

BETA
column chromatography

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