Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito

International Journal of Biological Macromolecules
Xiao-Qiang HanPeng-Fei Tu

Abstract

A water-soluble polysaccharide with a molar weight of 4.3x10(5)Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Composition, methylation analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy experiments were conducted to elucidate its structure. The results indicated that HBP is a glucan featuring a backbone of (1-->6)-linked-beta-d-glucopyranosyl residues, which occasionally branched at O-3 position on along the backbone and substituted by the side chains that consisting of (1-->3)-linked-beta-d-glucopyranosyl, (1-->4)-linked-beta-d-glucopyranosyl and non-reducing end beta-d-glucopyranosyl residues. Immunological activity evaluation by H(3)-thymidine incorporation method revealed that HBP can significantly stimulate the proliferation of the cultured mice spleen lymphocyte in a dose-dependent manner, thus, HBP is a promising potential immunomodulator that can be used as healthcare food or medicine against pathogens and tumors.

Citations

Mar 26, 2014·International Journal of Molecular Sciences·Fa-Yan MengXue-Hua Li
Apr 10, 2012·International Journal of Biological Macromolecules·Qi YangJingjie Wang
Dec 12, 2012·Carbohydrate Polymers·Andriy Synytsya, Miroslav Novák
May 29, 2021·International Journal of Biological Macromolecules·Yuxi GuoPin Gong

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