Structure elucidation of mammalian TCDD-metabolites

H PoigerC Schlatter


Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.


Jul 24, 2010·Applied Microbiology and Biotechnology·T Sakaki, Eiji Munetsuna
Jan 1, 1984·The International Journal of Biochemistry·L CantoniR Ruggieri
Nov 19, 2002·FEMS Microbiology Letters·Toshio Mori, Ryuichiro Kondo
May 1, 1985·Environmental Health Perspectives·H R BuserP A Bergqvist
Sep 1, 1985·Environmental Health Perspectives·Linda S Birnbaum
Jan 1, 1984·Journal of Toxicology and Environmental Health·R D KimbroughG Fries
Jun 15, 1982·Experientia·M PhilippiR Hütter
Apr 17, 2013·Biotechnology and Applied Biochemistry·T SakakiShinichi Ikushiro
Aug 14, 2003·Biochemical and Biophysical Research Communications·Raku ShinkyoKuniyo Inouye
Jun 15, 1984·Toxicology and Applied Pharmacology·J B GreigA G Smith
Nov 16, 1982·Biochemical and Biophysical Research Communications·G H Elder, D M Sheppard
Jun 11, 2002·Archives of Biochemistry and Biophysics·T SakakiKuniyo Inouye
Jan 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J De JonghH Poiger
Jun 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H WeberC Schlatter
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Noriyuki KasaiKuniyo Inouye
Sep 4, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H HakkV J Feil
Nov 20, 2018·EFSA Journal·EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom

Related Concepts

Biliary Sludge
Metabolic Biotransformation
Thin Layer Chromatography
Canis familiaris
Mass Spectrometry

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