Structure elucidation of mammalian TCDD-metabolites

Experientia
H PoigerC Schlatter

Abstract

Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.

Citations

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Related Concepts

Tetrachlorodibenzodioxin
Metazoa
Biliary Sludge
Metabolic Biotransformation
Thin Layer Chromatography
Dioxins
Canis familiaris
Mass Spectrometry

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