Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis

Chemical Science
Jie ChenJoseph M Ready

Abstract

Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

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Citations

Aug 27, 2016·The Journal of Organic Chemistry·Moemi KantoMakoto Sasaki
Aug 24, 2018·Marine Drugs·Iván Cheng-Sánchez, Francisco Sarabia
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 19, 2020·Journal of Molecular Graphics & Modelling·Ahmed H Al SharieJosé L Medina-Franco

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Methods Mentioned

BETA
NMR

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