PMID: 12782155Jun 5, 2003Paper

Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties

Biochimica Et Biophysica Acta
Elizabeth FragopoulouConstantinos A Demopoulos

Abstract

The oxidative modification of low-density lipoproteins (LDL) is supposed to play a critical role in atherogenesis. During this oxidation a potent inflammatory phospholipid mediator named platelet activating factor (PAF) is produced, and it is believed to be the key for the initiation of the inflammation and therefore for the process of atherogenesis. From many studies, it is established that wine has beneficial effects on health, including protection against cardiovascular diseases. According to our point of view, the cardioprotective effect of wine may be attributed partly to the existence of PAF antagonists in red or white wine and partly to the existence of antioxidants that reduce the oxidation of LDL and therefore the production of PAF. In this study, wine compounds that antagonize PAF were isolated and purified via chromatographic procedures, and determined structurally using chemical, enzymatic and spectroscopic methods.

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Citations

Mar 5, 2016·European Journal of Nutrition·Marianna N XanthopoulouElizabeth Fragopoulou
Nov 25, 2004·Journal of Biochemical and Biophysical Methods·Ulrike EderHeinz Juan
Mar 23, 2017·Prostaglandins & Other Lipid Mediators·Chrysa ArgyrouElizabeth Fragopoulou
Nov 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anne R AlbersJane E Freedman
Mar 17, 2007·Critical Reviews in Food Science and Nutrition·Vinayak V KedageMinal Mhatre
May 2, 2017·Bioinorganic Chemistry and Applications·Vasiliki D PapakonstantinouAthanassios I Philippopoulos
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elizabeth FragopoulouYiannis Samaras
Jul 13, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Elizabeth Fragopoulou, Smaragdi Antonopoulou

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