Structure, Function, and Development of the Tectorial Membrane: An Extracellular Matrix Essential for Hearing

Current Topics in Developmental Biology
Richard J Goodyear, Guy P Richardson

Abstract

The tectorial membrane is an extracellular matrix that lies over the apical surface of the auditory epithelia in the inner ears of reptiles, birds, and mammals. Recent studies have shown it is composed of a small set of proteins, some of which are only produced at high levels in the ear and many of which are the products of genes that, when mutated, cause nonsyndromic forms of human hereditary deafness. Quite how the proteins of the tectorial membrane are assembled within the lumen of the inner ear to form a structure that is precisely regulated in its size and physical properties along the length of a tonotopically organized hearing organ is a question that remains to be fully answered. In this brief review we will summarize what is known thus far about the structure, protein composition, and function of the tectorial membrane in birds and mammals, describe how the tectorial membrane develops, and discuss major events that have occurred during the evolution of this extracellular matrix.

Citations

Dec 29, 2018·Synapse·Thomas M CoateMansa Gurjar
Nov 26, 2019·Journal of Neuroscience Research·Anwen BullenRuth Taylor
Mar 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Clark Elliott StrimbuAnders Fridberger
Jun 24, 2020·Development·Elizabeth Carroll Driver, Matthew W Kelley
Dec 6, 2018·Journal of Human Genetics·Alex Marcel Moreira DiasRegina Célia Mingroni-Netto

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