Structure, function and regulation of the vacuolar (H+)-ATPase

Annual Review of Cell and Developmental Biology
T H Stevens, M Forgac

Abstract

The vacuolar (H+)-ATPases (or V-ATPases) function in the acidification of intracellular compartments in eukaryotic cells. The V-ATPases are multisubunit complexes composed of two functional domains. The peripheral V1 domain, a 500-kDa complex responsible for ATP hydrolysis, contains at least eight different subunits of molecular weight 70-13 (subunits A-H). The integral V0 domain, a 250-kDa complex, functions in proton translocation and contains at least five different subunits of molecular weight 100-17 (subunits a-d). Biochemical and genetic analysis has been used to identify subunits and residues involved in nucleotide binding and hydrolysis, proton translocation, and coupling of these activities. Several mechanisms have been implicated in the regulation of vacuolar acidification in vivo, including control of pump density, regulation of assembly of V1 and V0 domains, disulfide bond formation, activator or inhibitor proteins, and regulation of counterion conductance. Recent information concerning targeting and regulation of V-ATPases has also been obtained.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R D NelsonS Gluck
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D ChatterjeeR Baron
Jul 1, 1992·The Plant Cell·J P GogartenL Taiz
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·M Forgac
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·M Forgac
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·B J BowmanE J Bowman
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·H SzeS Lai
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·P M Kane, T H Stevens
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·Y AnrakuY Ohya
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·N Nelson
Aug 1, 1992·Journal of Bioenergetics and Biomembranes·H KibakJ P Gogarten
Oct 1, 1992·Journal of Bioenergetics and Biomembranes·W S AllisonS R Paik
Oct 1, 1992·Journal of Bioenergetics and Biomembranes·A E Senior
Nov 6, 1992·Science·J M White
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T NoumiN Nelson
Jan 1, 1991·Advances in Enzymology and Related Areas of Molecular Biology·H S Penefsky, R L Cross
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H Nelson, N Nelson
Apr 30, 1990·Biochemical and Biophysical Research Communications·M AppersonM P Yaffe
Jul 31, 1990·Biochemical and Biophysical Research Communications·H HanadaM Futai
Jan 1, 1990·Annual Review of Cell Biology·B M Pearse, M S Robinson
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M MandelN Nelson
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R FuchsI Mellman
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C C CainR F Murphy
Jul 4, 1986·Cell·J E Rothman, S L Schmid
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S HirschS Gluck
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J BowmanK Altendorf
Mar 1, 1988·The Journal of Cell Biology·R G Anderson, L Orci
Sep 1, 1983·The Journal of Cell Biology·D J YamashiroF R Maxfield
Oct 1, 1983·The Journal of Cell Biology·J GlickmanQ Al-Awqati

❮ Previous
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Citations

Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H WieczorekW R Harvey
Mar 10, 2001·Molecular Reproduction and Development·S AndonianL Hermo
May 4, 2001·Molecular Reproduction and Development·C R MoralesS Lefrancois
Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Aug 21, 2008·Pediatric Surgery International·Toshiya MorimuraAkira Satomi
Dec 17, 2009·International Journal of Colorectal Disease·Felix RückertChristian Pilarsky
Mar 6, 2008·Pflügers Archiv : European journal of physiology·Shai Saroussi, Nathan Nelson
Apr 15, 2008·Cell and Tissue Research·Hiroyuki TabataYoh Wada
May 13, 2006·Journal of Bioenergetics and Biomembranes·Takeshi MurataYoshimi Kakinuma
Aug 2, 2003·Biochimica Et Biophysica Acta·Hiroto IzumiKimitoshi Kohno
Sep 28, 2000·Parasitology Today·I MacreadieL Tilley
Jun 5, 2003·Hearing Research·Hongwei DouDaniel Choo
May 18, 2001·Trends in Cell Biology·J Zimmerberg
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shigehisa HiroseYoshio Takei
May 19, 2001·Microbes and Infection·J Pieters
Apr 16, 2002·Trends in Plant Science·Heven SzeLincoln Taiz
Sep 13, 2005·Oncogene·Christophe NicotGenoveffa Franchini
Dec 12, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M YamakiM Horikoshi
Sep 30, 2000·International Journal of Andrology·G KawaY Moriyama
Oct 3, 2001·Molecular Microbiology·O BaderB Hube
Dec 12, 2001·Molecular Microbiology·T EricksonP R Williamson
Aug 3, 2002·Journal of Neurochemistry·Mitsuko HayashiYoshinori Moriyama
Feb 9, 2011·Médecine sciences : M/S·Oussama El Far, Michael Seagar
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Adam AmsterdamNancy Hopkins
Sep 15, 2010·The Journal of Biological Chemistry·Norbert KartnerMorris F Manolson
Jan 18, 2011·The Journal of Biological Chemistry·Chunjuan Huang, Amy Chang
Nov 6, 2002·The Journal of Experimental Medicine·Edda FiebigerAna-Maria Lennon-Duménil
Jun 12, 2002·Molecular Biology of the Cell·Matthias GeyerB Matija Peterlin
Feb 26, 2000·Molecular Biology of the Cell·C BucciB van Deurs

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Datasets Mentioned

BETA
GM38006

Methods Mentioned

BETA
chemical modification
two-hybrid
glycosylation
gel filtration

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