Structure-function associations in hippocampus in bipolar disorder.

Biological Psychology
Lara G ChepenikHilary P Blumberg

Abstract

Hippocampus volume decreases and verbal memory deficits have been reported in bipolar disorder (BD) as independent observations. We investigated potential associations between these deficits in subjects with BD. Hippocampus volumes were measured on magnetic resonance images of 31 subjects with BD and 32 healthy comparison (HC) subjects. The California Verbal Learning Test-Second Edition (CVLT) assessed verbal memory function in these subjects. Compared to the HC group, the BD group showed both significantly smaller hippocampus volumes and impaired performance on CVLT tests of immediate, short delay and long delay cued and free recall. Further, smaller hippocampus volume correlated with impaired performance in BD. Post hoc analyses revealed a trend towards improved memory in BD subjects taking antidepressant medications. These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits.

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Citations

Apr 26, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Kesavan MuralidharanLakshmi N Yatham
Feb 25, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Trisha ChakrabartyLakshmi N Yatham
Dec 17, 2014·Journal of Affective Disorders·Mara Otten, Martijn Meeter
Oct 27, 2016·European Archives of Psychiatry and Clinical Neuroscience·Kalliopi TournikiotiAthanasios Douzenis
Aug 9, 2020·Frontiers in Human Neuroscience·Hui Juan ChenFeng Chen
Feb 6, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Kyu-Man HanByung-Joo Ham
Mar 17, 2020·Frontiers in Psychiatry·Francesco BenedettiRoberto Furlan
Dec 8, 2020·Journal of Affective Disorders·Caroline V OttKamilla W Miskowiak
Nov 17, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Adriano José Maia Chaves FilhoDanielle S Macedo
Jul 11, 2021·Acta Psychiatrica Scandinavica·Julian MacoveanuKamilla Woznica Miskowiak
Nov 7, 2021·Neuroscience and Biobehavioral Reviews·Steve EatonGraeme Fairchild

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