Structure-function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging

Human Brain Mapping
Paolo BonifaziJesus M Cortes

Abstract

Physiological aging affects brain structure and function impacting morphology, connectivity, and performance. However, whether some brain connectivity metrics might reflect the age of an individual is still unclear. Here, we collected brain images from healthy participants (N = 155) ranging from 10 to 80 years to build functional (resting state) and structural (tractography) connectivity matrices, both data sets combined to obtain different connectivity features. We then calculated the brain connectome age-an age estimator resulting from a multi-scale methodology applied to the structure-function connectome, and compared it to the chronological age (ChA). Our results were twofold. First, we found that aging widely affects the connectivity of multiple structures, such as anterior cingulate and medial prefrontal cortices, basal ganglia, thalamus, insula, cingulum, hippocampus, parahippocampus, occipital cortex, fusiform, precuneus, and temporal pole. Second, we found that the connectivity between basal ganglia and thalamus to frontal areas, also known as the fronto-striato-thalamic (FST) circuit, makes the major contribution to age estimation. In conclusion, our results highlight the key role played by the FST circuit in the proc...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Computational Neuroscience·Peter Beim GrabenSerafim Rodrigues
Apr 8, 2020·Journal of Clinical Medicine·Javier De Las HerasJesus M Cortes
Jan 14, 2020·NeuroImage. Clinical·Antonio Jimenez-MarinJesus M Cortes
Mar 6, 2021·PLoS Computational Biology·Javier RaseroTimothy Verstynen
May 29, 2021·Developmental Neurobiology·Nino LomidzeTamar Lordkipanidze
Aug 14, 2021·BMC Neurology·Jo WrigglesworthJoanne Ryan

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