Structure-function relationship of anticoagulant and antithrombotic well-defined sulfated polysaccharides from marine invertebrates

Advances in Food and Nutrition Research
Vitor H Pomin

Abstract

Marine sulfated polysaccharides (MSPs), such as sulfated fucans (SFs), sulfated galactans (SGs), and glycosaminoglycans (GAGs) isolated from invertebrate animals, are highly anionic polysaccharides capable of interacting with certain cationic proteins, such as (co)-factors of the coagulation cascade during clotting-inhibition process. Primarily, these molecular complexes between MSPs and coagulation-related proteins seem to be driven mostly by electrostatic interactions. However, through a systematic comparison using several novel well-defined sulfated polysaccharides composed of repetitive oligosaccharides with clear sulfation patterns, it was proved that those molecular interactions are essentially regulated by the stereochemistry of the glycans (which depends on a conjunction of anomeric configurations, sugar types, conformational preferences, glycosylation, and sulfation sites), rather than just a mere consequence of the electronegative density charges (mainly from number of sulfate groups). Here, we present an overview about the structure-function relationship of the invertebrate MSPs with regular structures as potential anticoagulant and antithrombotic agents, as pathologies related to the cardiovascular system are one of...Continue Reading

Citations

Mar 19, 2014·Frontiers in Cellular and Infection Microbiology·Vitor H Pomin, Paulo A S Mourão
Jan 14, 2017·International Journal of Biological Macromolecules·Yony Román OchoaThales Ricardo Cipriani
May 20, 2014·Glycoconjugate Journal·Vitor H Pomin
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana AlvesMadalena Pinto
Jul 11, 2018·Marine Drugs·Ariana A Vasconcelos, Vitor H Pomin

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