Jan 1, 1989

Structure-function relationship of interleukin-1 giving new insights for its therapeutic potential

Biotherapy
D Boraschi, A Tagliabue

Abstract

The pleiotropic activities of IL-1 have fostered a series of studies on the structure-function relationship in these proteins. In fact, the attempt to dissociate different biological functions of IL-1 should simplify its therapeutic use. About human IL-1 beta, which has been more extensively studied in this respect, enzymatic cleavage of the precursor protein to generate the mature polypeptide appears necessary for its full biological activity. The almost complete integrity of the mature IL-1 beta protein is also required for its ability to bind to the receptor and trigger cellular functions. However, by the use of monoclonal antibodies and recombinant or synthetic peptides, it has been possible to map some IL-1 beta regions important for different activities. Both N-terminal and C-terminal fragments are important for receptor binding. A domain around amino acids 187-204 is apparently involved in the hyperalgesic effects of IL-1 beta. Finally, the fragment in position 163-171 appears to be responsible for a restricted series of the IL-1 beta activities, mainly directed to the immune system, although irrelevant for inflammation-related effects and unable of binding to the IL-1R. It is thus possible, within the sequence of a cyto...Continue Reading

Mentioned in this Paper

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Immune System
IL1R1
Carboxy-Terminal Amino Acid
Structure-Activity Relationship
Amino Acids, I.V. solution additive
Interleukin-1
Cytokinesis of the Fertilized Ovum
Isolate compound

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