Structure-function relationships of pheromones of the ciliate Euplotes raikovi with mammalian growth factors: cross-reactivity between Er-1 and interleukin-2 systems

Experimental Cell Research
A VallesiP Luporini

Abstract

Diffusible protein signals of the ciliate Euplotes raikovi, denoted as pheromones, have functionally been linked with prototypic growth factors of animal cells by the demonstration that they not only induce a temporary cell union in mating pairs, by acting in a paracrine-like fashion, but can also bind to cells in autocrine fashion and promote their vegetative (mitotic) proliferation. It is now shown that pheromone Er-1 is capable of binding to the alpha and beta chains of the multimeric IL-2 receptor on mammalian cells and that IL-2 can, in turn, bind to the putative cell receptor of this pheromone. Similarities in the IL-2 and Er-1 structures support these findings and raise controversial implications with regard to their evolutionary significance.

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Citations

Mar 24, 2006·BMC Neuroscience·Celeste R Wirsig-WiechmannRichard C Feldhoff
Nov 26, 2010·Human Genomics·Chad BrockerVasilis Vasiliou
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sherry D PainterGregg T Nagle
May 1, 2005·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Jakob SuckaleAlister W Dodds
Sep 27, 2007·The FEBS Journal·Scott F CumminsCatherine H Schein
Jun 28, 2016·European Journal of Protistology·Pierangelo LuporiniAdriana Vallesi
Apr 7, 2012·Autoimmune Diseases·Carlos A Cañas, Felipe Cañas
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elisabetta CatalaniDavide Cervia
Apr 10, 2004·The Journal of Experimental Biology·Jolanta WiejakElzbieta Wyroba

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