PMID: 18406760Oct 1, 1996Paper

Structure-function studies of human TSH: new advances in design of glycoprotein hormone analogs

Trends in Endocrinology and Metabolism : TEM
M W SzkudlinskiB D Weintraub

Abstract

Recent progress in structure-function studies of glycoprotein hormones has provided new insights into the molecular mechanisms of action of these hormones and has further supported the concept that physiological modulation of assembly, bioactivity, and clearance of these hormones is dependent on specific structural components. This review emphasizes current advances in the structure-function relationships of human TSH, which have contributed to further elucidation of common and hormone specific features within the glycoprotein hormones family. Novel strategies are now being applied to investigate the role of individual structural elements. The principks discovered in such studies are essential to understand the physiological regulation of hormone bioactivity and allow for the rational design of novel analogs with potential therapeutic applications.

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Citations

Mar 28, 2002·Physiological Reviews·Mariusz W SzkudlinskiBruce D Weintraub
Aug 5, 2009·Biotechnology and Applied Biochemistry·Frank J RiskeKerry H White
May 7, 2013·Endocrine Reviews·Gunnar KleinauHeike Biebermann
Nov 18, 2000·The Journal of Biological Chemistry·F A FaresZ Kraiem
Feb 18, 2010·Expert Review of Endocrinology & Metabolism·Susanne NeumannMarvin C Gershengorn
May 17, 2011·Thyroid : Official Journal of the American Thyroid Association·Julia ReinfelderOlaf Prante
Oct 1, 1996·Nature Biotechnology·M W SzkudlinskiB D Weintraub
Jun 12, 1999·Thyroid : Official Journal of the American Thyroid Association·B D Weintraub, M W Szkudlinski
Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·Michael Weissel
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·L Persani
Dec 2, 2004·Expert Opinion on Pharmacotherapy·Mariusz W Szkudlinski
Apr 15, 2000·Methods : a Companion to Methods in Enzymology·M W SzkudlinskiB D Weintraub
Apr 9, 1998·Baillière's Clinical Endocrinology and Metabolism·J SandersB R Smith

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