PMID: 9164466Mar 1, 1997Paper

Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1

Nature Structural Biology
B Sha, M Luo

Abstract

Matrix protein (M1) of influenza virus is a bifunctional protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously. The X-ray crystal structure of the N-terminal portion of type A influenza virus M1-amino acid residues 2-158-has been determined at 2.08 A resolution at pH 4.0. The protein forms a dimer. A highly positively charged region on the dimer surface is suitably positioned to bind RNA while the hydrophobic surface opposite the RNA binding region may be involved in interactions with the membrane. The membrane-binding hydrophobic surface could be buried or exposed after a conformational change.

References

May 15, 1992·Cell·A Helenius
Aug 1, 1991·Trends in Genetics : TIG·R A Lamb, C M Horvath
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Nov 11, 1989·Nucleic Acids Research·L Wakefield, G G Brownlee
Nov 1, 1980·Journal of Virology·D J BucherJ F Davis
Jul 1, 1994·Proteins·L Holm, C Sander
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Jul 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·B Sha, M Luo

❮ Previous
Next ❯

Citations

Sep 30, 2000·Bioorganic & Medicinal Chemistry Letters·H KuribayashiH Mihara
Jul 17, 2001·RNA·S TchatalbachevG Hobom
Nov 10, 2009·Nature Structural & Molecular Biology·Junfeng WangJames J Chou
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Piotr NeumannMilton T Stubbs
Aug 16, 2000·The EMBO Journal·A DessenW Weissenhorn
Jun 18, 2002·The EMBO Journal·Martin GaudierMarcel Knossow
Jul 19, 2013·Journal of the Royal Society, Interface·David SchleyBenjamin W Neuman
Nov 23, 2000·Journal of Virology·P Gómez-PuertasA Portela
Oct 9, 2002·Journal of Virology·Ann H ReidJeffery K Taubenberger
Nov 20, 2002·Journal of Virology·Teresa Liu, Zhiping Ye
Oct 1, 2011·Molekuliarnaia biologiia·A L KsenofontovL A Baratova
Mar 4, 2014·PLoS Genetics·Matthieu FollJeffrey D Jensen
Aug 30, 2008·PLoS Pathogens·Tommy Tsan-Yuk LamFrederick Chi-Ching Leung
Nov 13, 2012·PLoS Pathogens·Edward C HutchinsonErvin Fodor
Nov 26, 2009·Uirusu·Tadasuke NaitoKyosuke Nagata
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lixin MaCarol Beth Post
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·A V ShishkovA V Galkin
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·J E PadillaT O Yeates
May 3, 2005·FEBS Letters·Ina KrausWolfgang Garten
Jul 5, 2005·Expert Opinion on Investigational Drugs·C Cianci, M Krystal
Jun 19, 2012·Drug Discovery Today·Juan DuHuan-Xiang Zhou
Oct 26, 2010·Virus Research·Hatice AkarsuYoshihiro Kawaoka
Sep 2, 2004·Proteins·Kevin B MurrayJanet M Thornton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.