Structure of a single whisker representation in layer 2 of mouse somatosensory cortex

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kelly B ClancyDaniel E Feldman

Abstract

Layer (L)2 is a major output of primary sensory cortex that exhibits very sparse spiking, but the structure of sensory representation in L2 is not well understood. We combined two-photon calcium imaging with deflection of many whiskers to map whisker receptive fields, characterize sparse coding, and quantitatively define the point representation in L2 of mouse somatosensory cortex. Neurons within a column-sized imaging field showed surprisingly heterogeneous, salt-and-pepper tuning to many different whiskers. Single whisker deflection elicited low-probability spikes in highly distributed, shifting neural ensembles spanning multiple cortical columns. Whisker-evoked response probability correlated strongly with spontaneous firing rate, but weakly with tuning properties, indicating a spectrum of inherent responsiveness across pyramidal cells. L2 neurons projecting to motor and secondary somatosensory cortex differed in whisker tuning and responsiveness, and carried different amounts of information about columnar whisker deflection. From these data, we derive a quantitative, fine-scale picture of the distributed point representation in L2.

Citations

Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Taekeun KimHyung-Bae Kwon
May 21, 2016·Frontiers in Neural Circuits·Alexander Naka, Hillel Adesnik
Nov 22, 2016·Nature Communications·Luc EstebanezJean-François Léger
Jan 18, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ada X YeeLu Chen
Nov 5, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James A Bednar, Stuart P Wilson
Nov 2, 2017·Nature Communications·Nicolas C PégardHillel Adesnik
May 2, 2018·Nature Neuroscience·Alan R MardinlyHillel Adesnik
Dec 23, 2016·Journal of Neurophysiology·Yadollah Ranjbar-Slamloo, Ehsan Arabzadeh
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Feb 20, 2015·Journal of Neurophysiology·Audrey J SederbergJason N MacLean
May 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Samat MoldakarimovTerrence J Sejnowski
Jan 9, 2019·Frontiers in Neural Circuits·Ayako HayashiKenichi Ohki
Apr 2, 2019·The Journal of Physiology·Yadollah Ranjbar-Slamloo, Ehsan Arabzadeh
Jul 25, 2019·Nature Neuroscience·Keven J Laboy-JuárezDaniel E Feldman
May 30, 2020·Neuroscience Research·Tatsuo K Sato
Jun 29, 2021·Annals of Neurology·Hyun Yong KohJeong Ho Lee
Dec 17, 2016·ACS Chemical Neuroscience·Kasey S Girven, Dennis R Sparta

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