Structure of amylase-binding protein A of Streptococcus gordonii: a potential receptor for human salivary α-amylase enzyme

Protein Science : a Publication of the Protein Society
Ashish SethiPaul R Gooley

Abstract

Amylase-binding protein A (AbpA) of a number of oral streptococci is essential for the colonization of the dental pellicle. We have determined the solution structure of residues 24-195 of AbpA of Streptococcus gordonii and show a well-defined core of five helices in the region of 45-115 and 135-145. (13) Cα/β chemical shift and heteronuclear (15) N-{(1) H} NOE data are consistent with this fold and that the remainder of the protein is unstructured. The structure will inform future molecular experiments in defining the mechanism of human salivary α-amylase binding and biofilm formation by streptococci.

References

Apr 15, 1992·FEMS Microbiology Letters·C W DouglasJ P Gwynn
Nov 1, 1992·Infection and Immunity·F A ScannapiecoM J Levine
Dec 31, 1990·Biochemical and Biophysical Research Communications·F A ScannapiecoM J Levine
Dec 15, 1994·FEMS Microbiology Letters·J P Gwynn, C W Douglas
Jan 1, 1994·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F A Scannapieco
Jul 1, 1994·Advances in Dental Research·C W Douglas
Nov 1, 1995·Journal of Biomolecular NMR·F DelaglioA Bax
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Nov 21, 1997·Journal of Molecular Biology·P GüntertK Wüthrich
Nov 24, 1999·Journal of Clinical Microbiology·A E BrownF A Scannapieco
Jun 3, 2004·Genome Research·Gavin E CrooksSteven E Brenner
Apr 25, 2009·Acta Crystallographica. Section D, Biological Crystallography·Kevin P MadaussShawn P Williams
May 12, 2010·Nucleic Acids Research·Liisa Holm, Päivi Rosenström
Jul 4, 2012·Journal of Biomolecular NMR·Pedro SerranoKurt Wüthrich

❮ Previous
Next ❯

Citations

Mar 31, 2016·International Journal of Environmental Research and Public Health·Cynthia WanCatherine Bielajew
Apr 22, 2017·BMC Microbiology·Elaine M HaaseFrank A Scannapieco
Jan 9, 2020··Z. M. YusofN. M. Nadri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.