Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution.

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Steven B LarsonAlexander McPherson

Abstract

Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5'-monophosphate (U5P). Solution of the crystal structure revealed that the enzyme was selectively bound to U5P, with the pyrimidine ring of U5P residing in the pyrimidine-binding site at Thr45. The structure was refined to an R factor of 0.197 and an R(free) of 0.253.

References

Apr 19, 1988·Biochemistry·A WlodawerG L Gilliland
Apr 28, 1968·Journal of Molecular Biology·B W Matthews
Mar 25, 1993·Nucleic Acids Research·S L Moodie, J M Thornton
Dec 17, 1996·Biochemistry·A A FedorovS C Almo
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·C SadasivanM Vijayan
Oct 26, 1999·Acta Crystallographica. Section D, Biological Crystallography·J W Pflugrath
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Feb 19, 2002·Chemical Reviews·Ronald T. Raines
Feb 22, 2002·Acta Crystallographica. Section D, Biological Crystallography·R BerisioL Mazzarella
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·J E LadnerG L Gilliland
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Jan 27, 2005·The FEBS Journal·Cara L JenkinsRonald T Raines
Jun 23, 2005·Journal of the American Chemical Society·Heather BeachJ Patrick Loria
Jul 28, 2005·The FEBS Journal·George N HatzopoulosNikos G Oikonomakos
Nov 15, 2006·Journal of Structural Biology·Alexander McPherson, Bob Cudney
Mar 1, 2007·Acta Crystallographica. Section D, Biological Crystallography·Steven B LarsonAlexander McPherson
Jul 4, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Vicky G TsirkoneDemetres D Leonidas

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Citations

Oct 1, 2010·Journal of Applied Crystallography·Joseph R LuftEdward H Snell
Oct 12, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zhen ZhangQ Ping Dou

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