PMID: 11310941Apr 20, 2001Paper

Structure of carotid artery in baboon and rat and differences in their response to endothelial denudation angioplasty

Annals of Medicine
D du ToitP Häyry

Abstract

Most studies dealing with vascular response to injury have been conducted using rodent and rabbit models, although it is expected that the response to injury in these species is dissimilar from man. Here we compare the structure of native carotid artery in rat and baboon and the response of these vessels to endothelial denudation angioplasty. In both species, the carotid is a musculoelastic artery. Only baboon carotid has a distinct intima, correlating in size with the weight of male baboons. Complete endothelial denudation of left carotid was performed on eight male baboons and 24 male rats by applying an equivalent pull force with a Fogarthy catheter. The animals were sacrificed prior to and 15 min and 2, 3, 4, 7, 14 and 28 days postinjury, one baboon and three rats per time point. Re-endothelialization in the baboon was complete already on day 4, whereas in the rat it was still incomplete on day 28. The proliferative response to injury was far smaller in the baboon than in the rat, the intimal area increased only by 5-fold in baboon compared with 25-fold in rat, and the number of intimal nuclei by 4-fold in baboon compared with 12-fold in rat. Complete compensatory remodelling of the lumen size occurred in the baboon, wherea...Continue Reading

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Citations

Nov 30, 2006·Transplantation·Minnie M Sarwal, Li Li
Jan 2, 2007·Transplantation·Pekka Häyry
Apr 21, 2006·Immunological Reviews·Minnie M Sarwal
Oct 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einari AavikPekka Häyry
Mar 30, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einari AavikPekka Hayry

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