PMID: 6160211Jun 1, 1980Paper

Structure of developing frog neuromuscular junctions

Journal of Neurocytology
M S Letinsky, K Morrison-Graham

Abstract

Developing neuromuscular junctions in the cutaneous pectoris muscle from tadpoles and and postmetamorphic frogs were studied in the light microscope. Presynaptic nerve terminals and postsynaptic acetylcholinesterase (AChE) activity simultaneously demonstrated at these developing junctions using the NBT-AChE method. The earliest nerve contacts studied were small enlargements at the ends of unmyelinated axons. As development progressed, single nerve contacts, often with growth cones, grew in length, generally parallel to the long axis of the myotube. Further endplate maturation was characterized by individual terminal processes developing secondary and tertiary branches, ultimately leading to highly complex terminal arborizations. The initial synaptic contact at developing neuromuscular junctions was made by a single axon, but with further development these same synaptic sites became multiply innervated. The occurrence of multiple innervation was a transient phenomena; the multiple synaptic inputs were eliminated during further maturation. The time course of synapse elimination was protracted, with some multiple innervation even persisting in relatively large adult frogs. The first nerve contacts were generally devoid of observab...Continue Reading

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Citations

Jan 1, 1983·Biological cybernetics·J L GouzéJ P Changeux
Jun 1, 1980·Journal of Neurocytology·M S Letinsky, P A Decino
Dec 1, 1985·Journal of Neurocytology·M R BennettN A Lavidis
Aug 1, 1981·Journal of Neurocytology·M B Rheuben, A E Kammer
May 1, 1983·Developmental Biology·K Lynch, C P Ko
Oct 1, 1983·Developmental Biology·K Morrison-Graham
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Z P Xie, M M Poo
Jun 18, 2011·The Journal of Comparative Neurology·Michael A FoxJeff W Lichtman
Mar 1, 1988·Experimental Neurology·D C Linden, M S Letinsky
Mar 1, 1988·Experimental Neurology·D C LindenM S Letinsky
Sep 11, 1998·Journal of Neurobiology·J E HirschM L Fine
Jan 23, 1989·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M R Bennett, J Robinson
Nov 1, 1992·The Journal of Comparative Neurology·F F Omerza, K E Alley
Jan 1, 1990·Journal of Neurobiology·A A Herrera, M J Werle
Apr 1, 1982·Journal of Chemical Ecology·R J ProkopyJ S Morgante
Jun 1, 1988·Journal of Neurobiology·C L JordanA P Arnold
Aug 8, 1986·The Journal of Comparative Neurology·D P Kuffler
Oct 1, 1990·Journal of Neurobiology·K E Alley

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