PMID: 9532780Apr 9, 1998Paper

Structure of genes for cecropin A and an inducible nuclear protein that binds to the promoter region of the genes from the silkworm, Bombyx mori

Bioscience, Biotechnology, and Biochemistry
Y YamanoI Morishima

Abstract

Cecropins are a family of antibacterial peptide synthesized in insects as a response to bacterial infection. To study the regulation of the immune genes in insects, two cecropin A genes were cloned and sequenced from the silkworm, Bombyx mori. The two genes, CecA1 and CecA2, encoded identical preprocecropin A, having one intron of 609 bp and 929 bp, respectively. The 5'-upstream regions of the genes contained a NF-kappa B like element and IL-6-RE Type I element. Electrophoretic mobility shift assay revealed that a nuclear protein of fat body which specifically bound to the kappa B-like element was activated by injection of the larvae with peptidoglycan.

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Citations

Sep 29, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Li WangYi Pang
Jan 16, 2010·Archives of Insect Biochemistry and Physiology·Hiromitsu TanakaMinoru Yamakawa
May 2, 2000·The Journal of Biological Chemistry·K Taniai, S Tomita
Feb 6, 2021·Pathogens and Disease·Daniel F Q Smith, Arturo Casadevall
Jul 30, 1999·Developmental and Comparative Immunology·M Yamakawa, H Tanaka
Jun 3, 2004·Experimental Parasitology·Arundhati ChoudhuryMonoj K Roy

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