Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity

Planta medica
Alessandra BracaNunziatina De Tommasi

Abstract

Twenty-three kaurane-type diterpenes 1 - 23, including twenty new natural products 1 - 20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED (50) values in the range of 10 - 20 microg/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.

Citations

Jan 24, 2009·Journal of Natural Products·Qiuwen MiSteven M Swanson
Sep 30, 2005·Natural Product Reports·James R Hanson
Jul 22, 2008·Free Radical Biology & Medicine·Patrizia NigroMaria Antonietta Belisario
May 12, 2016·Natural Products and Bioprospecting·Rui ChuMing-Hua Qiu
Jul 16, 2019·Natural Product Research·Do Tien LamPhan Van Kiem

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