Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins

Proceedings of the National Academy of Sciences of the United States of America
J C LougheedT M Handel

Abstract

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Sep 1, 1974·Journal of Bacteriology·F C NeidhardtD F Smith
Feb 16, 1995·Nature·T Pawson
Jan 5, 1993·Journal of Molecular Biology·G D Van DuyneJ Clardy
May 1, 1994·Protein Science : a Publication of the Protein Society·L YoungD G Covell
Jan 1, 1994·Progress in Biophysics and Molecular Biology·A MusacchioM Saraste
Jan 5, 1996·The Journal of Biological Chemistry·A K BosserhoffR Buettner
Feb 9, 1996·The Journal of Biological Chemistry·U H Dietz, L J Sandell
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·A B SparksB K Kay
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Apr 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A K BosserhoffL J Sandell
Apr 25, 1997·Journal of Molecular Biology·C Burge, S Karlin
Dec 19, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A K BosserhoffR Hein
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger, J Berendzen
May 20, 1999·Nature Structural Biology·A PerrakisV S Lamzin
Jul 8, 2000·The Journal of Investigative Dermatology·M GolobA K Bosserhoff
Aug 10, 2000·Nature Structural Biology·M A VerdeciaJ P Noel
Dec 2, 2000·Journal of Molecular Biology·F CordierL K Nicholson
Jan 11, 2001·Protein Science : a Publication of the Protein Society·S M Larson, A R Davidson
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4

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Citations

Jun 9, 2004·Gene Expression Patterns : GEP·A K BosserhoffR Buettner
Feb 13, 2002·Molecular and Cellular Biology·Markus MoserReinhard Buettner
Nov 30, 2006·Biological Chemistry·Raphael StollAnja-Katrin Bosserhoff
Jan 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·James Holton, Tom Alber
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Piotr JachimczakUlrich Bogdahn
May 25, 2011·The Journal of Cell Biology·Deanna G WilsonMark J Solloway
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Jennifer Schmidt, Anja-Katrin Bosserhoff
Sep 1, 2011·The EMBO Journal·Vivek Malhotra, Patrik Erlmann
Aug 10, 2004·Biophysical Journal·Wei LiJeffrey Skolnick
Mar 18, 2008·Developmental Biology·Sui LinJohn M Shannon
May 7, 2016·Scientific Reports·King Tuo YipRaphael Stoll
Oct 1, 2003·Proteins·Wei LiJeffrey Skolnick
Oct 18, 2006·International Journal of Cancer. Journal International Du Cancer·Stephanie Arndt, Anja K Bosserhoff
Jun 23, 2004·Oncogene·Ina PoserAnja K Bosserhoff
Nov 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anja-Katrin BosserhoffTad A Holak
Mar 7, 2006·The Journal of Biological Chemistry·Richard BauerAnja-Katrin Bosserhoff
Jan 1, 2014·Experimental Dermatology·Alexander Riechers, Anja Katrin Bosserhoff
Nov 27, 2019·FEBS Letters·Xian WeiQing Zhao
Feb 15, 2003·The Journal of Biological Chemistry·Anja K BosserhoffClaus Hellerbrand
Jan 28, 2021·Annual Review of Biochemistry·I Raote, V Malhotra

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