PMID: 2124703Dec 1, 1990Paper

Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species

Proceedings of the National Academy of Sciences of the United States of America
K GustafssonD H Sachs

Abstract

As part of our studies of the class II genes of miniature swine, we have isolated and characterized cDNA clones corresponding to DRB genes from two major histocompatibility complex homozygous strains. Comparison of the sequences of these clones to those of human DRB genes revealed a striking amino acid homology between the hypervariable residues of SLA-DRBc and the human DRB1-0101 allele. The percentage of differences in these residues between the pig DRBc allele and the human DRB1-0101 allele was significantly lower (29%) than that between the DRB1-0101 allele and all other human alleles (average, 66.2%). This similarity was not seen in a comparison of the number of silent substitutions, by which the swine DRBc and the human DRB-0101 differed. Since phenotypic selection operates at the level of protein products rather than nucleotide sequences, these data suggest the existence of selective mechanisms that have resulted in similar hypervariable regions in certain alleles even in these widely disparate species. Consistent with this hypothesis, an examination of available murine and bovine class II sequences revealed a homology in hypervariable residues between the human DRB1-1401 allele and the mouse E beta s allele as well as a...Continue Reading

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Citations

Oct 1, 1994·Veterinary Immunology and Immunopathology·J K Lunney
Feb 28, 2002·Veterinary Immunology and Immunopathology·Tomoko Hosokawa-KanaiYoshitsugu Matsumoto
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