Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats

Molecular Nutrition & Food Research
Martin BeaumontMarion Leclerc

Abstract

Few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics. Rats received for 3 weeks two diets of identical composition but based on lipid-protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion. LFE diet led to higher abundance, when compared to the GCE, of Lactobacillaceae (Lactobacillus reuteri) in the ileum, higher β-diversity of the caecum mucus-associated bacteria. In contrast, the LFE diet led to a decrease in Akkermansia municiphila in the caecum. This coincided with heavier caecum content and higher amount of isovalerate in the LFE group. LFE diet induced an increased expression of (i) amino acid transporters in the ileum (ii) glucagon in the caecum, together with an elevated level of GLP-1 in portal plasma. However, these intestinal effects were not associated with modification of food intake or body weight gain. Overall, the structure of protein emulsion in food affects the expression of amino acid transporters and gut peptides concomitantly with m...Continue Reading

References

Jun 1, 1991·The Journal of Applied Bacteriology·J H Cummings, G T Macfarlane
Aug 1, 1993·The Proceedings of the Nutrition Society·B H Hirst
Dec 3, 1999·The American Journal of Clinical Nutrition·M ArmandD Lairon
Jun 2, 2000·Journal of Clinical Microbiology·S R LyonsE J Leys
Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Mar 31, 2005·American Journal of Physiology. Renal Physiology·Mary E HandlogtenI David Weiner
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Mar 24, 2009·FEMS Microbiology Ecology·Jean-Pierre FuretGérard Corthier
Apr 17, 2009·The American Journal of Clinical Nutrition·Radhika V SeimonChristine Feinle-Bisset
Jul 16, 2009·Environmental Microbiology·Julien TapMarion Leclerc
Dec 19, 2009·Amino Acids·François BlachierDaniel Tomé
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Mar 11, 2011·The American Journal of Clinical Nutrition·Wendy R RussellHarry J Flint
Jul 30, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mina C MojtahediEllen M Evans
Sep 3, 2011·Science·Gary D WuJames D Lewis
Sep 10, 2011·Bioinformatics·Tanja Magoč, Steven L Salzberg
Nov 29, 2011·Molecular Nutrition & Food Research·Karen WindeyKristin Verbeke
Mar 29, 2012·The Proceedings of the Nutrition Society·Rojo RasoamananaDaniel Tomé
Apr 25, 2012·Gut·Patricia LepageJoel Doré
Sep 14, 2012·Nature·Valentina Tremaroli, Fredrik Bäckhed
Nov 14, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Karen P ScottSylvia H Duncan
Nov 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anne-Marie DavilaDaniel Tomé
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Mar 19, 2014·Cell Host & Microbe·Dirk GeversRamnik J Xavier
Apr 5, 2014·PLoS Computational Biology·Paul J McMurdie, Susan Holmes
Jun 28, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xinxin LiuAnne-Marie Davila
Dec 3, 2014·Current Opinion in Biotechnology·Patrice D Cani, Matthias Van Hul
Jan 3, 2015·Food & Function·J E NortonI T Norton

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