Structure of proteins involved in synaptic vesicle fusion in neurons

Annual Review of Biophysics and Biomolecular Structure
A T Brunger

Abstract

The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Structures of the SNARE complex, synaptotagmin III, nSec1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effectors provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models.

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Jul 9, 2004·Nucleic Acids Research·Jinfeng Liu, Burkhard Rost
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Methods Mentioned

BETA
NMR
electron microscopy
nuclear magnetic resonance
GTPase

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