Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Rosa GrenhaKeith S Wilson

Abstract

Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.

References

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Citations

Feb 22, 2012·Acta Crystallographica. Section D, Biological Crystallography·Paola DessantiSteven E Ealick
May 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Nadia Helena MartinsMario Tyago Murakami
Nov 3, 2010·Infection and Immunity·Amy JenkinsSusan Welkos
Aug 21, 2007·Biochimica Et Biophysica Acta·Francesco SgarrellaPiero Luigi Ipata
May 15, 2016·Journal of Molecular Evolution·Mark K GunnellByron J Adams
Jun 6, 2018·Acta Crystallographica. Section F, Structural Biology Communications·Vladimir I TimofeevInna P Kuranova
Apr 7, 2007·The Journal of Biological Chemistry·Giovanna CostanzoErnesto Di Mauro
Jan 28, 2010·Journal of Medicinal Chemistry·Dimitrios G Bouzianas

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