Structure of the 14-3-3ζ-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3

Acta Crystallographica. Section F, Structural Biology Communications
Sheng DingYaqin Zhu

Abstract

The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3ζ-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found.

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Citations

Apr 4, 2017·Acta Crystallographica. Section F, Structural Biology Communications·Yongjian LuJianyong Wu
Sep 5, 2019·Cells·Abdalla AbdrabouZhixiang Wang
Sep 22, 2017·Scientific Reports·Nikolai N SluchankoAlfred A Antson

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