Structure of the chromatin binding (chromo) domain from mouse modifier protein 1

The EMBO Journal
L J BallErnest D Laue

Abstract

The structure of a chromatin binding domain from mouse chromatin modifier protein 1 (MoMOD1) was determined using nuclear magnetic resonance (NMR) spectroscopy. The protein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-terminal alpha-helix. The structure reveals an unexpected homology to two archaebacterial DNA binding proteins which are also involved in chromatin structure. Structural comparisons suggest that chromo domains, of which more than 40 are now known, act as protein interaction motifs and that the MoMOD1 protein acts as an adaptor mediating interactions between different proteins.

References

Sep 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Reuter, P Spierer
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·C E AlfaJ S Hyams
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R Paro, D S Hogness
Dec 1, 1990·Trends in Genetics : TIG·R Paro
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J C EissenbergS C Elgin
Mar 1, 1990·Immunology Today·E J Leonard, T Yoshimura
Jan 1, 1988·Annual Review of Genetics·D Solter
Jan 1, 1983·Annual Review of Genetics·S M Gartler, A D Riggs
Dec 16, 1983·Biochemical and Biophysical Research Communications·M RanceK Wüthrich
Jul 1, 1995·Trends in Genetics : TIG·P BaumannS P Jackson
Aug 25, 1995·Nucleic Acids Research·R Aasland, A F Stewart
Apr 14, 1995·Journal of Molecular Biology·H BaumannT Härd
Jan 1, 1994·Methods in Enzymology·D S Wishart, B D Sykes
Feb 1, 1995·Current Opinion in Biotechnology·R T ClowesE D Laue
Dec 1, 1993·Current Opinion in Cell Biology·R Paro
Sep 5, 1993·Journal of Molecular Biology·L Holm, C Sander
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V DelmasR P Perry

❮ Previous
Next ❯

Citations

Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D O JonesP B Singh
Oct 2, 2009·Plant Molecular Biology·Xi CaoDe Ye
Mar 17, 2004·Biochimica Et Biophysica Acta·Nicholas L AdkinsPhilippe T Georgel
Jun 11, 2002·Biochemical and Biophysical Research Communications·Kyu-Kye Hwang, Howard J Worman
Nov 26, 2002·Trends in Genetics : TIG·Malcolm F White, Stephen D Bell
Jun 1, 2002·Gene·Raul Alvarez-Venegas, Zoya Avramova
Jun 26, 1998·Current Opinion in Cell Biology·G Cavalli, R Paro
Jun 4, 1998·Current Opinion in Genetics & Development·L L Wallrath
Jul 17, 1998·Current Opinion in Structural Biology·L Holm
May 18, 2001·Trends in Cell Biology·T Jenuwein
Feb 11, 2003·Trends in Biochemical Sciences·Sebastian Maurer-StrohChris P Ponting
Dec 20, 2002·Journal of Structural Biology·Prim B Singh, Spyros D Georgatos
Jun 6, 2000·Trends in Plant Science·L Williams, G Grafi
Jun 5, 2001·Nature Reviews. Molecular Cell Biology·R Marmorstein
Apr 12, 2012·The Journal of Biological Chemistry·Alexandria N RichartJean O Thomas
Dec 2, 2000·The EMBO Journal·N KourmouliS D Georgatos
Sep 22, 2001·The EMBO Journal·S A JacobsS Khorasanizadeh
Jan 16, 2003·Nucleic Acids Research·Xiaohong WitmerZoya Avramova
May 29, 2003·Nucleic Acids Research·Juliette SalvaingFrédérique Peronnet
Aug 25, 2000·Molecular and Cellular Biology·G WangP B Singh
Mar 22, 2001·Molecular and Cellular Biology·J F Smothers, S Henikoff
Aug 24, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J Adam Hall, Philippe T Georgel
Apr 5, 2005·Archaea : an International Microbiological Journal·Annamaria GuagliardiMosè Rossi
May 23, 2012·International Journal of Plant Genomics·Anton NovikovOlga Novikova
Jan 17, 2007·Genome Biology·Gwen LomberkRaul Urrutia
Apr 16, 2013·PloS One·Francesca MunariMarkus Zweckstetter
Aug 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuhong LiLori L Wallrath
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·H HuangC D Allis
Apr 8, 2000·Current Opinion in Genetics & Development·J C Eissenberg, S C Elgin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.