Structure of the fibronectin type 1 module

Nature
M BaronI D Campbell

Abstract

The rapid accumulation of sequence data has provided insight into the evolution of proteins and led to the identification of 'mosaic proteins'. These proteins have evolved by duplication, insertion and deletion of a common pool of structural units or modules, yet their biological functions are diverse. They are involved in cell adhesion and migration, embryogenesis and the pathways of blood clotting, fibrinolysis and complement. The modular units are defined by 'consensus sequences' which often include conserved disulphide bonds. Despite the available sequence information, little is known of the tertiary structure of mosaic proteins. If, however, the 'consensus structure' of the modules were known, valuable structural information could be inferred about a wide variety of proteins and biological systems. An important mosaic protein is fibronectin, an extracellular matrix protein that consists of three types of module (see refs 3, 7 for reviews). Here we describe the structure of the fibronectin type 1 module which appears twelve times in fibronectin and is also found in factor XII and tissue plasminogen activator. The module was produced using a yeast expression system and the structure was determined in solution using 1H NMR. T...Continue Reading

References

Jan 1, 1985·Biotechnology & Genetic Engineering Reviews·S M KingsmanN A Roberts
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·G M Clore, A M Gronenborn
Jun 1, 1989·Immunology Today·K B Reid, A J Day
Jan 1, 1988·Annual Review of Biochemistry·E Ruoslahti
May 20, 1988·Cell·B Furie, B C Furie
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J BrakeP J Barr
Nov 1, 1982·The Journal of Cell Biology·R O Hynes, K M Yamada
Oct 1, 1981·European Journal of Biochemistry·V E Koteliansky Venyaminov SYu
Jan 23, 1987·Science·A T BrüngerM Karplus

❮ Previous
Next ❯

Citations

Jun 1, 1991·Journal of Molecular Graphics·M J Ramos
Oct 1, 1990·Biochimie·J Janin
Oct 1, 1991·Current Opinion in Cell Biology·J Engel
Aug 1, 1991·Current Opinion in Biotechnology·J R Coggins
Jan 1, 1991·Trends in Biochemical Sciences·M BaronI D Campbell
Nov 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·J R Potts, I D Campbell
Aug 2, 2006·Molecular BioSystems·Natalia ShpiroRodolfo Marquez
Feb 20, 1999·The Biochemical Journal·A A RostagnoL I Gold
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michèle C EratIoannis Vakonakis
Oct 16, 2010·The Journal of Biological Chemistry·Lisa M MaurerDeane F Mosher
Feb 24, 2001·Protein Science : a Publication of the Protein Society·Y KurodaS Yokoyama
Jan 1, 1997·Annual Review of Biochemistry·C Chothia, E Y Jones
Oct 1, 1992·Current Opinion in Cell Biology·D F MosherJ A McDonald
Feb 3, 2016·Angewandte Chemie·Aleeza FarrukhAránzazu del Campo
Apr 21, 2010·Experimental Cell Research·Ian R EllisSeth L Schor
May 6, 2004·Journal of Biomedical Materials Research. Part a·Loren Baugh, Viola Vogel
Dec 1, 1994·Current Opinion in Structural Biology·G Wagner, D F Wyss
Jun 20, 1991·Journal of Molecular Biology·D G NormanI D Campbell
Aug 3, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Yong Mao, Jean E Schwarzbauer
Aug 11, 2010·FEMS Microbiology Reviews·Brian HendersonMark A Williams
Aug 6, 2015·Advances in Wound Care·Haylee BachmanThomas H Barker
Jun 5, 2015·Nature Communications·Susanna Maria FrühViola Vogel
Jun 15, 2010·Structure·Richard J Bingham, Jennifer R Potts
Oct 1, 1994·Current Opinion in Cell Biology·J R Potts, I D Campbell
May 18, 2016·Critical Reviews in Biochemistry and Molecular Biology·Lisa M MaurerDeane F Mosher
May 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I D Campbell, M Baron
Jan 19, 1996·The Journal of Biological Chemistry·K House-PompeoM Höök
Oct 16, 2002·The Journal of Biological Chemistry· SachchidanandIain D Campbell
Jul 13, 2004·The Journal of Biological Chemistry·Ulrich Schwarz-LinekJennifer R Potts

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Next ❯

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