PMID: 8950166Nov 11, 1996Paper

Structure of the human retinoic acid receptor beta 1 gene

Biochimica Et Biophysica Acta
A ToulouseW E Bradley

Abstract

We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal transcription start site with a secondary site 23 bp further upstream in both SCLC and fetal tissues. The sequences isolated were CpG-rich between -60 and the 3' end of the first exon but there were no features like a TATA-box or an Inr element. In several important aspects, the human RAR beta 1 differs from its mouse counterpart. The 5'-UTR is 823 bp long and is encoded by four exons (vs two in the mouse giving a 477 bp UTR). The 5' end of the mouse cDNA has been mapped to a 67 bp CT repeat which is absent in our sequences. We were also unable to find evidence for a human isoform RAR beta 3 which is widely expressed in mouse tissues.

Citations

Oct 6, 1997·Genome Research·J W Fickett, A G Hatzigeorgiou
Apr 12, 2014·Journal of Cellular and Molecular Medicine·Marina Inés FlaminiLaura María Vargas-Roig
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M SommerK Swisshelm
Jan 10, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Céline MoisonAnne-Laure Guieysse-Peugeot
Aug 14, 2020·Journal of Receptor and Signal Transduction Research·Sneha Bharti, Harini Chowdary Vadlamudi
Nov 17, 2005·Molecular and Cellular Biology·Mingqiang RenNicoletta Sacchi
Dec 7, 2007·Cancer Investigation·Vered StearnsNancy E Davidson
Jun 24, 2016·Expert Opinion on Therapeutic Patents·Aleksandra MarchwickaGeoffrey Brown
Aug 17, 2000·Journal of the National Cancer Institute·A K VirmaniA F Gazdar

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