Structure of the major carrot allergen Dau c 1

Acta Crystallographica. Section D, Biological Crystallography
Zora Marković-HousleyK Hoffmann-Sommergruber

Abstract

Dau c 1 is a major allergen of carrot (Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 A, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1.

Citations

Apr 4, 2014·TheScientificWorldJournal·Mau SinhaTej P Singh
Jul 16, 2013·Biophysical Chemistry·Judit Somkuti, László Smeller
Mar 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R DollnerM F Kramer
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Jan 8, 2013·The FEBS Journal·Humberto FernandesMariusz Jaskolski
Jul 31, 2013·Methods : a Companion to Methods in Enzymology·Fabio Dall'antoniaWalter Keller
Jun 27, 2020·Current Opinion in Allergy and Clinical Immunology·Karin Hoffmann-Sommergruber, Lennart M Roesner
Mar 30, 2021·Plant Science : an International Journal of Experimental Plant Biology·Kentaro Fujita, Hideyuki Inui

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