Aug 1, 1989

Structure of the mitochondrial outer membrane channel derived from electron microscopy of 2D crystals

Journal of Bioenergetics and Biomembranes
C A Mannella

Abstract

A structural model for the channel in the mitochondrial outer membrane is presented, derived from electron microscopic studies of two-dimensional crystals and inferences from the primary structure of the 30-kDa polypeptide which forms the channel. The channel is represented as a cylindrical beta-barrel, with a carbon backbone diameter of 3.8 nm. The axial projection of the cylinder is divided radially into four sectors by four interchannel contact points. These sectors are characterized in terms of their interactions with lipid and macromolecular ligands, and in terms of the presence or absence of exposed basic amino acids.

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Citations

Mentioned in this Paper

Crystal - Body Material
Neurospora
Amino Acids, I.V. solution additive
Ion Channel
Optical Image Reconstruction
Electron Microscopy, Diagnostic
Mitochondria
Voltage-Dependent Anion Channels
Electron Microscopy
Intracellular Membranes

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