Structure of the mitochondrial outer membrane channel derived from electron microscopy of 2D crystals.

Journal of Bioenergetics and Biomembranes
C A Mannella

Abstract

A structural model for the channel in the mitochondrial outer membrane is presented, derived from electron microscopic studies of two-dimensional crystals and inferences from the primary structure of the 30-kDa polypeptide which forms the channel. The channel is represented as a cylindrical beta-barrel, with a carbon backbone diameter of 3.8 nm. The axial projection of the cylinder is divided radially into four sectors by four interchannel contact points. These sectors are characterized in terms of their interactions with lipid and macromolecular ligands, and in terms of the presence or absence of exposed basic amino acids.

References

Dec 11, 1975·Biochimica Et Biophysica Acta·C A Mannella, W D Bonner
May 1, 1992·Journal of Structural Biology·C A MannellaD D'Arcangelis
Aug 1, 1987·Journal of Bioenergetics and Biomembranes·C A Mannella
Aug 1, 1987·Journal of Bioenergetics and Biomembranes·M ForteC A Mannella
Jul 1, 1986·Journal of Ultrastructure and Molecular Structure Research·C A Mannella, J Frank
Dec 11, 1987·Biochimica Et Biophysica Acta·M ColombiniT König
Aug 1, 1989·Journal of Bioenergetics and Biomembranes·H TedeschiC A Mannella
Aug 1, 1989·Journal of Bioenergetics and Biomembranes·E Blachly-DysonM Forte
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A MannellaJ Frank
Feb 1, 1980·Journal of Microscopy·H P Ting-Beall
Jan 1, 1962·Cold Spring Harbor Symposia on Quantitative Biology·D L CASPAR, A KLUG

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Citations

Feb 1, 1992·Journal of Bioenergetics and Biomembranes·C A MannellaJ Dias
Feb 15, 1990·Experientia·C A Mannella
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·J Song, M Colombini
Aug 17, 2010·Trends in Biochemical Sciences·Sebastian HillerKornelius Zeth
Dec 14, 2011·Biochimica Et Biophysica Acta·Fabrice HombléMartine Prévost
Oct 4, 2005·Biophysical Journal·Alexander G KomarovMarco Colombini
May 8, 2007·Biophysical Journal·Wenzhi TanMarco Colombini
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·M C Sorgato, O Moran
Feb 1, 1992·Journal of Bioenergetics and Biomembranes·C A MannellaM Colombini
Aug 11, 2018·Journal of the American Chemical Society·Zhao ZhaoMahmoud L Nasr
Jun 13, 1998·Biochemistry·J D CorteseC R Hackenbrock

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