Structure of the multidrug resistance P-glycoprotein

Seminars in Cancer Biology
C F HigginsR C Ford

Abstract

In order to elucidate the mechanism by which the multidrug resistance P-glycoprotein extrudes cytotoxic drugs from the cell, and particularly the number and nature of the drug binding site(s), knowledge of the structure of P-gp is essential. A considerable body of genetic and biochemical data has accrued which gives insights into P-gp structure and function. These data are critically reviewed, particularly in relation to the low resolution structure of P-gp which has recently been determined by electron microscopy. P-gp is one of the best characterised of the ABC transporters and these structure-function studies may have more general implications.

Citations

Jul 9, 2002·British Journal of Haematology·Rodrigo T CaladoRoberto P Falcão
Jan 29, 2000·Molecular Microbiology·J Li, B P Rosen
May 2, 2002·Journal of Hematotherapy & Stem Cell Research·Alexander A Shtil
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Mar 31, 2011·World Journal of Gastroenterology : WJG·Sara De IudicibusGiuliana Decorti
Jan 11, 2014·World Journal of Gastroenterology : WJG·Alessio ProvenzaniNatale D'Alessandro
Apr 3, 2013·Genetics and Molecular Research : GMR·O F KhabourN M Mhaidat
Dec 18, 2013·The Journal of Chemical Physics·Shan-Yan ChangYan Sun
Sep 1, 2007·Expert Opinion on Medical Diagnostics·Joel A LeffertsGregory J Tsongalis
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S EkinsP W Swaan
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S-F Zhou
Dec 2, 2014·Pharmacology & Therapeutics·Renata SilvaFernando Remião
Dec 12, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Inês J SousaMiguel X Fernandes
Feb 6, 2008·Journal of Structural Biology·Eszter Hazai, Zsolt Bikádi
Oct 1, 2015·Pharmacogenomics·Eva CuzzoniGiuliana Decorti
Jan 18, 2011·Chemical Biology & Drug Design·Andreia PalmeiraMiguel X Fernandes
Dec 4, 2004·The Journal of Hand Surgery·George S AthwalDavid R Pichora
Nov 11, 1999·Current Biology : CB·J T KarttunenP J Lehner
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Ching-Ping TsengKelvin Chingchung Tseng
Dec 11, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C G MachadoR P Falcão
Dec 29, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marianne SchmidtFlorian Hoppe
Jul 23, 2004·Physiological Reviews·Stephen H Wright, William H Dantzler
Jul 7, 2005·Chembiochem : a European Journal of Chemical Biology·Jörg WollmannAndreas Hilgeroth
Nov 13, 2004·The Journal of Antimicrobial Chemotherapy·J FordD J Back
Nov 9, 2007·Journal of Bioenergetics and Biomembranes·Saroj VelamakanniHendrik W van Veen
May 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Jean-Luc MorettiZeynep Burak
Apr 25, 2013·Journal of Computer-aided Molecular Design·Rameshwar PrajapatiAbhay T Sangamwar
May 5, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V Yu GrigorevO A Raevsky
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·M DemeuleR Béliveau
Feb 24, 2000·Biopolymers·J P TamZ Miao
Mar 23, 2017·World Journal of Gastroenterology : WJG·Elke Cario
Mar 23, 2011·Drug Metabolism and Drug Interactions·Yamsani Shravan KumarYamsani Madhusudan Rao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.