PMID: 6411350Aug 1, 1983Paper

Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon

Cell
D LarhammarP A Peterson

Abstract

The murine major histocompatibility complex I region encodes two class II antigens, I-A and I-E. From a mouse spleen DNA cosmid library of the b haplotype, we isolated a clone containing the entire I-A beta gene and a separate exon encoding a beta-chain second domain (A beta 2). The A beta gene, encompassing more than 6 kb, is encoded by six exons corresponding to the different domains of the A beta polypeptide. The translated A beta amino acid sequence displays 73% homology to human DC beta chains; homologies to other subsets of human beta chains are lower, establishing that I-A corresponds structurally to DC. The A beta 2 exon is about 20 kb centromeric to the A beta gene. Its translated amino acid sequence includes all the conserved amino acids of other class II beta-chain second domains. It shows about 60% homology to each of three subsets of human beta chains available for comparison, and to the A beta chain. No A beta 2 first domain exon has been detected with A beta or DC beta probes.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R BreathnachP Chambon
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J Charron, H O McDevitt
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Jan 1, 1983·Annual Review of Immunology·L HoodB Malissen
Nov 11, 1982·Nucleic Acids Research·F G GrosveldR A Flavell
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D J MathisH O McDevitt
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C O BenoistH O McDevitt
Mar 1, 1983·Cell·D J MathisH O McDevitt
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H HamadaT Kakunaga
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C AuffrayJ L Strominger
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D LarhammarP A Peterson
Jan 1, 1981·Annual Review of Biochemistry·G Kreil
Jan 1, 1982·Annual Review of Biochemistry·W R Jelinek, C W Schmid
Oct 1, 1981·Cell·S H ShenO Smithies
Feb 21, 1980·Nature·S ArnottR L Ratliff

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Citations

Jan 1, 1992·Immunogenetics·O S EgorovI K Egorov
Jan 1, 1987·Immunogenetics·P A Barran, W R McMaster
Jan 1, 1988·Immunogenetics·G J MavrothalassitisJ Papamatheakis
Jan 1, 1986·Immunogenetics·H F MeunierJ Trowsdale
Jan 1, 1985·Immunogenetics·M BukaraJ Klein
Jan 1, 1985·Immunogenetics·S J Eccles, W R McMaster
Jan 1, 1985·Journal of Molecular Evolution·M B SoaresA Efstratiadis
Jan 1, 1990·Immunogenetics·J KleinS W Hunt
Oct 1, 1992·Molecular Immunology·I R SandersonP R Harmatz
Jan 1, 1987·Immunology Today·D Isenberg, Y Shoenfeld
Jan 1, 1990·Human Immunology·N L Reinsmoen, F H Bach
Oct 1, 1987·Genetical Research·M GolubićJ Klein
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D LarhammarP A Peterson
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J GorskiB Mach
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J M Boss, J L Strominger
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K OkadaJ L Strominger
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G Widera, R A Flavell
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D LarhammarP A Peterson
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L Mengle-Gaw, H O McDevitt
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R N GermainJ Y Tou
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P EstessH O McDevitt
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P A ShermanJ P Ting
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Acha-Orbea, H O McDevitt
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R HolmdahlL Andersson
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A L Hughes, M Nei
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J SkowronskiD Hanahan
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J X SheE K Wakeland
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M F FlajnikM Kasahara
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A S Lundberg, H O McDevitt
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M KasaharaM F Flajnik
Oct 1, 1991·Journal of Biomolecular Structure & Dynamics·J Tripathi, S K Brahmachari

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